지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 361 - 369 (9page)
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초록· 키워드
오류제보하기
Transplanting fetal kidney cells (FKCs) can regenerate kidney. This requires in vitro expansion in cell number to acquire enough cells for transplantation. However, FKCs may change their cellular characteristics during expansion and, thus, may not regenerate kidney tissue upon transplantation. We investigated how cell culture period affects cellular characteristics and in vivo regenerative potential of FKCs. As the passage number increased, cell growth rate and colony forming ability decreased while senescence and apoptosis increased.
To examine in vivo regenerative potential, FKCs cultured through different numbers of passages were implanted into the parenchyma of kidneys of immunodeficient mice using fibrin gel for 4 wk. Histological analyses showed passage-dependent kidney tissue regeneration, and the regeneration was better when cells from lower number of passages were implanted. This result shows that in vitro culture of FKCs significantly affects the cell characteristics and in vivo tissue regenerative potential.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Blasco MA / 1997 / Telomere shortening and tumor formation by mouse cells lacking telomerase RNA / Cell 91 : 25 ~ 34
Campisi J / 2003 / Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes / Exp Gerontol 38 : 5 ~ 11
Dekel B / 2003 / Human and porcine early kidney precursors as a new source for transplantation / Nat Med 9 : 53 ~ 60
Deng W / 2005 / Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue / Tissue Eng 11 : 110 ~ 9
Dimri GP / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc Natl Acad Sci USA 92 : 9363 ~ 7
Campisi J / 2003 / Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes / Exp Gerontol 38 : 5 ~ 11
Dekel B / 2003 / Human and porcine early kidney precursors as a new source for transplantation / Nat Med 9 : 53 ~ 60
Deng W / 2005 / Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue / Tissue Eng 11 : 110 ~ 9
Dimri GP / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc Natl Acad Sci USA 92 : 9363 ~ 7
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