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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1 - 9 (9page)
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The worldwide prevalence of obesity is steadily increasing, nearly doubling between 1980 and 2008. Obesity is often associated with insulin resistance, a major risk factor for type 2 diabetes mellitus (T2DM): a costly chronic disease and serious public health problem. The underlying cause of T2DM is a failure of the beta cells of the pancreas to continue to produce enough insulin to counteract insulin resistance. Most current T2DM therapeutics do not prevent continued loss of insulin secretion capacity, and those that do have the potential to preserve beta cell mass and function are not effective in all patients. Therefore, developing new methods for preventing and treating obesity and T2DM is very timely and of great significance. Thereis now considerable literature demonstrating a link between inhibitory guanine nucleotide-binding protein (G protein) and G protein-coupled receptor (GPCR) signaling in insulin-responsive tissues and the pathogenesis of obesity and T2DM. These studies are suggesting new and emerging therapeutic targets for these conditions. In this review, we will discuss inhibitory G proteins and GPCRs that have primary actions in the beta cell and other peripheral sites as therapeutic targets for obesity and T2DM, improving satiety, insulin resistance and/or beta cell biology.
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참고문헌 (23)
참고문헌 신청
Bagger JI / 2011 / Impaired regulation of the incretin effect in patients with type 2 diabetes / J Clin Endocrinol Metab 96 : 737 ~ 745
Baggio LL / 2006 / Therapeutic approaches to preserve islet mass in type 2 diabetes / Annu Rev Med 57 : 265 ~ 281
DeFronzo RA / 1992 / Pathogenesis of type 2(non-insulin dependent)diabetes mellitus : a balanced overview / Diabetologia 35 : 389 ~ 397
Defronzo RA / 2009 / Banting lecture. From the triumvirate to the ominous octet:a new paradigm for the treatment of type 2 diabetes mellitus / Diabetes 58 : 773 ~ 795
Dotson CD / 2010 / T1R and T2R receptors:the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus / Curr Opin Investig Drugs 1
Baggio LL / 2006 / Therapeutic approaches to preserve islet mass in type 2 diabetes / Annu Rev Med 57 : 265 ~ 281
DeFronzo RA / 1992 / Pathogenesis of type 2(non-insulin dependent)diabetes mellitus : a balanced overview / Diabetologia 35 : 389 ~ 397
Defronzo RA / 2009 / Banting lecture. From the triumvirate to the ominous octet:a new paradigm for the treatment of type 2 diabetes mellitus / Diabetes 58 : 773 ~ 795
Dotson CD / 2010 / T1R and T2R receptors:the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus / Curr Opin Investig Drugs 1
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