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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 336 - 344 (9page)
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This phase 1 clinical trial tested the safety of
intramuscular gene transfer by using naked
plasmid DNA encoding the gene for VEGF, and
analyzed the potential therapeutic benefits in
patients with severe peripheral arterial disease
(PAD). This study was an open-labeled, doseescalating,
single-center trial on nine male patients
with severe debilitating PAD who had not
responded to conventional therapy. Seven had
Buerger's disease and two had arteriosclerosis
obliterans. Plasm id DNA (pCK) containing human
VEGF165 was given by eight intramuscular
injections in and around the area in need of new
blood vessels. The study evaluated three escalating
total doses (2, 4, and 8 mg of pCKVEGF165),
with half of each total dose given four
weeks apart. The follow-up duration was nine
months. The gene injections were well tolerated
without significant side effects or laboratory
abnormalities related to gene transfer. Three
patients showed transient edema in their extremities.
Ischemic pain of the affected limb was
relieved or improved markedly in six of seven
patients. Ischemic ulcers healed or improved in
four of six patients. The mean ankle-brachial
index (ABI) improved significantly. Six of nine
patients showed an increase in collateral vessels
around the injection sites demonstrated by
digital subtraction angiography. However, there
was no relationship between the degree of ABI
improvement and the dose given. Mean plasma
levels of VEGF d id not increase significantly.
In conclusion, intramuscular in jections of pCKVEGF165
can be performed safely to induce
therapeutic angiogenesis in patients with severe
PAD.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 199
/ 1996 / Clinical evidence of angiogenesis after arterial gene transferof phVEGF165 in patient with ischaemic limb : 370 ~ 4
/ 1997 / Use of synchrotron radiation microangiography to assessdevelopment of small collateral arteries in a rat model ofhindlimb ischemia shi (zaki y) : 805 ~ 8
/ 1998 / Constitutive expression of phVEGF165after intramuscular gene transfer promotes collateral vesseldevelopment in patients with critical limb ischemia : 1114 ~ 23
/ 1998 / Treatment of thromboangiitisobliterans : 964 ~ 73
/ 1996 / Clinical evidence of angiogenesis after arterial gene transferof phVEGF165 in patient with ischaemic limb : 370 ~ 4
/ 1997 / Use of synchrotron radiation microangiography to assessdevelopment of small collateral arteries in a rat model ofhindlimb ischemia shi (zaki y) : 805 ~ 8
/ 1998 / Constitutive expression of phVEGF165after intramuscular gene transfer promotes collateral vesseldevelopment in patients with critical limb ischemia : 1114 ~ 23
/ 1998 / Treatment of thromboangiitisobliterans : 964 ~ 73
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