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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
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- 1 - 12 (12page)
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The parasite Entamoeba histolytica causes amebic colitis and systemic amebiasis. Among the known amebic factors contributing to pathogenesis are signaling pathways involving heterotrimeric and Ras superfamily G proteins. Here, we review the current knowledge of the roles of heterotrimeric G protein subunits, Ras, Rho and Rab GTPase families in E. histolytica pathogenesis, as well as of their downstream signaling effectors and nucleotide cycle regulators. Heterotrimeric G protein signaling likely modulates amebic motility and attachment to and killing of host cells, in part through activation of an RGS-RhoGEF (regulator of G protein signaling–Rho guanine nucleotide exchange factor) effector. Rho family GTPases, as well as RhoGEFs and Rho effectors (formins and p21-activated kinases) regulate the dynamic actin cytoskeleton of E. histolytica and associated pathogenesis-related cellular processes, such as migration, invasion, phagocytosis and evasion of the host immune response by surface receptor capping. A remarkably large family of 91 Rab GTPases has multiple roles in a complex amebic vesicular trafficking system required for phagocytosis and pinocytosis and secretion of known virulence factors, such as amebapores and cysteine proteases. Although much remains to be discovered, recent studies of G protein signaling in E. histolytica have enhanced our understanding of parasitic pathogenesis and have also highlighted possible targets for pharmacological manipulation.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행
Abd Alla MD / 2012 / Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons (Papio sp.) / Vaccine 30 : 3068 ~ 3
Aikat BK / 1979 / The pathology and pathogenesis of fatal hepatic amoebiasis?a study based on 79 autopsy cases / Trans R Soc Trop Med Hyg 73 : 188 ~ 192
Anuar TS / 2012 / Molecular epidemiology of amoebiasis in Malaysia: highlighting the different risk factors of Entamoeba histolytica and Entamoeba dispar infections among Ora
Bansal D / 2006 / Drug resistance in amoebiasis / Indian J Med Res 123 : 115 ~ 118
Abd Alla MD / 2012 / Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons (Papio sp.) / Vaccine 30 : 3068 ~ 3
Aikat BK / 1979 / The pathology and pathogenesis of fatal hepatic amoebiasis?a study based on 79 autopsy cases / Trans R Soc Trop Med Hyg 73 : 188 ~ 192
Anuar TS / 2012 / Molecular epidemiology of amoebiasis in Malaysia: highlighting the different risk factors of Entamoeba histolytica and Entamoeba dispar infections among Ora
Bansal D / 2006 / Drug resistance in amoebiasis / Indian J Med Res 123 : 115 ~ 118
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