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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 622 - 632 (11page)
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Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines such as TNFα, IL-1β, and IL-6. Here, we demonstrated that STAMP2 protein physically interacts with and decreases the stability of hepatitis B virus X protein (HBx),thereby counteracting HBx-induced hepatic lipid accumulation and insulin resistance. STAMP2 suppressed the HBx-mediated transcription of lipogenic and adipogenic genes. Furthermore, STAMP2 prevented HBx-induced degradation of IRS1 protein, which mediates hepatic insulin signaling, as well as restored insulin-mediated inhibition of gluconeogenic enzyme expression, which are gluconeogenic genes. We also demonstrated reciprocal expression of HBx and STAMP2 in HBx transgenic mice. These results suggest that hepatic STAMP2 antagonizes HBx-mediated hepatocyte dysfunction, thereby protecting hepatocytes from HBV gene expression.
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참고문헌 (24)
참고문헌 신청
Arii M / 1992 / Identification of three essential regions of hepatitis B virus X protein for trans-activation function / Oncogene 7 : 397 ~ 403
Arner P / 2008 / Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance / J Clin Endocrinol Metab 93 :
Chen X / 2010 / STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes / Int J Mol Med 25 : 361 ~ 367
Fasshauer M / 2004 / Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes / FEBS Lett 560 : 153 ~ 157
Gavrilova O / 2003 / Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass / J Biol
Arner P / 2008 / Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance / J Clin Endocrinol Metab 93 :
Chen X / 2010 / STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes / Int J Mol Med 25 : 361 ~ 367
Fasshauer M / 2004 / Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes / FEBS Lett 560 : 153 ~ 157
Gavrilova O / 2003 / Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass / J Biol
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