지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 350 - 357 (8page)
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초록· 키워드
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B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor (BAFF-R) are expressed in B and T cells of RA synovium. The study was undertaken to identify the NF-κB signal pathway involved in the induction of BAFF-R in human B cells.
Immunohistochemical staining of NF-κB p65, NF-κB p50, BAFF, and BAFF-R was performed on sections of synovium from severe and mild RA and osteoarthritis (OA) patients. Peripheral blood mononuclear cells (PBMCs) were isolated from control and RA patients and B cells were isolated from controls. BAFF-R was analyzed by flow cytometry, realtime PCR and confocal staining after treatment with NF-κB inhibitors. NF-κB p65, NF-κB p50, BAFF, and BAFF-R were highly expressed in severe RA synovium relative to mild RA synovium or OA synovium. BAFF-R expression was reduced by NF-κB inhibitors in PBMCs and B cells from normal controls. We also showed reduction in expression of BAFF-R via inhibition of the NF-κB pathway in PBMCs of RA patients. BAFF/BAFF-R signaling is an important mechanism of pathogenesis in RA and that BAFF-R reduction by NF-κB blocking therapy is another choice for controlling B cells in autoimmune diseases such as RA.
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참고문헌 (23)
참고문헌 신청
Aupperle K / 2001 / NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes / J Immunol 166 : 2705 ~ 2711
Baeuerle PA / 1994 / Function and activation of NF-kappa B in the immune system / Annu Rev Immunol 12 : 141 ~ 179
Cambridge G / 2003 / Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis / Arthritis Rheum 48 : 2146 ~ 2154
Castro I / 2009 / B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and N
Do RK / 2000 / Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response / J Exp Med 192 : 953 ~ 964
Baeuerle PA / 1994 / Function and activation of NF-kappa B in the immune system / Annu Rev Immunol 12 : 141 ~ 179
Cambridge G / 2003 / Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis / Arthritis Rheum 48 : 2146 ~ 2154
Castro I / 2009 / B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and N
Do RK / 2000 / Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response / J Exp Med 192 : 953 ~ 964
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