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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 466 - 473 (8page)
이용수
초록· 키워드
오류제보하기
Glucocorticoids (GCs) are the most effective group of medications available to treat inflammation. Although most patients with inflammation respond to GC, a small group of patients exhibit persistent GC-resistance with prolonged inflammation. Previously, it was proposed that the GC-resistance is caused by low amount of human GC receptor (hGRα) and/or excessive presence of a GC receptor isoform, hGRβ that was generated from alternative splicing of the hGR message. We have tested this hypothesis by investigating correlation between the expression pattern of hGR mRNAs in patients with inflammatory nasal polyps and the effectiveness of GC treatment. We have performed reverse transcription PCR analysis of mRNAs coding each hGRα and hGRβ in nasal tissues. hGRα mRNA was more expressed in patients with nasal polyps than in normal subjects. However, the elevated hGRα mRNA expression was decreased after GC treatment. Compared with hGRα mRNA expression, level of hGRβ mRNA expression was very low in all groups. In patients, hGRβ mRNA was expressed at a similar level regardless of GC efficacy, indicating that there is no correlation between the GC sensitivity and the expression level of hGRβ mRNA. Thus, persistent GC-resistance is not associated with low expression of hGRα or overexpression of hGRβ.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ / Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation : 7284 ~ 91
/ / NF-kappa B as inducible trans-criptional activator of the granulocyte-macrophage colony- stimulating factor gene : 1281 ~ 6
/ / Novel mechanism of glucocor-ticoid-mediated gene repression Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene re-pression : 13289 ~ 95
/ / The genomic structure of the human glucocorticoid receptor : 7182 ~ 8
/ / The role of heat shock proteins in regulating the function and trafficking of the glucocorticoid receptor : 21455 ~ 8
/ / NF-kappa B as inducible trans-criptional activator of the granulocyte-macrophage colony- stimulating factor gene : 1281 ~ 6
/ / Novel mechanism of glucocor-ticoid-mediated gene repression Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene re-pression : 13289 ~ 95
/ / The genomic structure of the human glucocorticoid receptor : 7182 ~ 8
/ / The role of heat shock proteins in regulating the function and trafficking of the glucocorticoid receptor : 21455 ~ 8
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