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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 18 - 26 (9page)
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초록· 키워드
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The constrained α-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an α-helical structure are located close together, therefore D-Cys (dC) and L-Cys (C) were introduced at the positions, respectively, to make a dC-C disulfide bond in 28mer C-peptides. Accordingly, this study tested whether a dC-C disulfide bond would increase the α-helicity and anti-HIV-1 activity of peptides. A C-peptide can be divided into three domains, the N-terminal hy-drophobic domain (HPD), middle interface domain (IFD), and C-terminal hydrogen domain (HGD), based on the binding property with an N-peptide. In general, the dC-C modifications in HPD enhanced the anti-HIV-1 activity, while those in IFD and HGD resulted in no or much less activity. The modified α-helicity than the native peptides, while those with higher activity showed an almost similar or slightly increased α-helicity. Therefore, the present results suggest that the introduction of a dC-C bridge in the N-terminal hydrophobic domain of a C-peptide may be useful for enhancing the anti-HIV-1 activity.
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참고문헌 (22)
참고문헌 신청
/ / Atomic structure of a
/ 1995 / High-titer packaging cells producing recombinant retro-viruses resistant to human serum 69 : 7430 ~ 6
/ 1996 / A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5 and CKR-2b as fusion cofactors 85 : 1149 ~ 58
/ 1996 / HIV-1 entry cofactor:functional cDNA cloning of a seven-trans-membrane, G protein-coupled receptor. 272 : 872 ~ 7
/ 1996 / The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates 85 : 1135 ~ 48
/ 1995 / High-titer packaging cells producing recombinant retro-viruses resistant to human serum 69 : 7430 ~ 6
/ 1996 / A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5 and CKR-2b as fusion cofactors 85 : 1149 ~ 58
/ 1996 / HIV-1 entry cofactor:functional cDNA cloning of a seven-trans-membrane, G protein-coupled receptor. 272 : 872 ~ 7
/ 1996 / The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates 85 : 1135 ~ 48
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