지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 517 - 524 (8page)
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초록· 키워드
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Idiopathic pulmonary fibrosis (IPF) is a lethal parenchymal lung disease characterized by myofibroblast proliferation. Alveolar epithelial cells (AECs) are thought to produce myofibroblasts through the epithelial to mesenchymal transition (EMT). Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptors whose activation is associated with renal fibrosis during diabetes and liver fibrosis. RAGE is expressed at low basal levels in most adult tissues except the lung. In this study, we evaluated the interaction of ligand advanced glycation end products (AGE) with RAGE during the epithelial to myofibroblast transition in rat AECs. Our results indicate that AGE inhibited the TGF-β-dependent alveolar EMT by increasing Smad7expression, and that the effect was abolished by RAGE siRNA treatment. Thus, the induction of Smad7 by the AGE-RAGE interaction limits the development of pulmonary fibrosis by inhibiting TGF-β-dependent signaling in AECs.
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참고문헌 (22)
참고문헌 신청
Bargagli E / 2009 / Controversial role of RAGE in the pathogenesis of idiopathic pulmonary fibrosis / Resp Physiol Neurobiol 165 : 119 ~ 120
Bohlender JM / 2005 / Advanced glycation end products and the kidney / Am J Physiol Renal Physiol 289 : F645 ~ F659
Brett J / 1993 / Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues / Am J Pathol 143 : 1699 ~ 1712
Brownlee M / 1988 / Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications / N Engl J Med 318 : 1315 ~ 1321
Chavakis T / 2003 / The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment / J Exp Med 198 :
Bohlender JM / 2005 / Advanced glycation end products and the kidney / Am J Physiol Renal Physiol 289 : F645 ~ F659
Brett J / 1993 / Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues / Am J Pathol 143 : 1699 ~ 1712
Brownlee M / 1988 / Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications / N Engl J Med 318 : 1315 ~ 1321
Chavakis T / 2003 / The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment / J Exp Med 198 :
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