지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 525 - 537 (13page)
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초록· 키워드
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Although 4,4'-diaminodiphenylsulfone (DDS, dapsone)has been used to treat several dermatologic conditions,including Hansen disease, for the past several decades, its mode of action has remained a topic of debate. We recently reported that DDS treatment significantly extends the lifespan of the nematode C. elegans by decreasing the generation of reactive oxygen species. Additionally, in in vitro experiments using non-phagocytic human fibroblasts, we found that DDS effectively counteracted the toxicity of paraquat (PQ).
In the present study, we extended our work to test the protective effect of DDS against PQ in vivo using a mouse lung injury model. Oral administration of DDS to mice significantly attenuated the lung tissue damage caused by subsequent administration of PQ.
Moreover, DDS reduced the local expression of mRNA transcripts encoding inflammation-related molecules,including endothelin-1 (ET-1), macrophage inflammatory protein-1α (MIP-1α), and transforming growth factor-β(TGF-β). In addition, DDS decreased the PQ-induced expression of NADPH oxidase mRNA and activation of protein kinase Cμ (PKCμ). DDS treatment also decreased the PQ-induced generation of superoxide anions in mouse lung fibroblasts. Taken together,these data suggest the novel efficacy of DDS as an effective protective agent against oxidative stress-induced tissue damages.
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참고문헌 (24)
참고문헌 신청
Anderson R / 1987 / Regulation by the antioxidants ascorbate, cysteine, and dapsone of the increased extracellular and intracellular generation of reactive oxidants by activa
Autor AP / 1974 / Reduction of paraquat toxicity by superoxide dismutase / Life Sci 14 : 1309 ~ 1319
Bhaiya P / 2006 / Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts / Toxicol Appl Pharmacol 215 : 158 ~ 167
Bonneh-Barkay D / 2005 / Redox cycling of the herbicide paraquat in microglial cultures / Brain Res Mol Brain Res 134 : 52 ~ 56
Bradshaw TP / 1997 / Formation of free radicals and protein mixed disulfides in rat red cells exposed to dapsone hydroxylamine / Free Radic Biol Med 22 : 1183 ~ 1193
Autor AP / 1974 / Reduction of paraquat toxicity by superoxide dismutase / Life Sci 14 : 1309 ~ 1319
Bhaiya P / 2006 / Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts / Toxicol Appl Pharmacol 215 : 158 ~ 167
Bonneh-Barkay D / 2005 / Redox cycling of the herbicide paraquat in microglial cultures / Brain Res Mol Brain Res 134 : 52 ~ 56
Bradshaw TP / 1997 / Formation of free radicals and protein mixed disulfides in rat red cells exposed to dapsone hydroxylamine / Free Radic Biol Med 22 : 1183 ~ 1193
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