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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 176 - 185 (10page)
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The molecular mechanism playing a role in the development
of prostate cancer (PCA) is not well defined. We
decided to determine the changes in gene expression
in PCA tissues and to compare them to those in noncancerous
samples. Prostate tissue samples were collected
by needle biopsy from 21 PCA and 10 benign
prostate hyperplasic (BPH) patients. Total RNA was
isolated, cDNA was synthesized, and gene expression
levels were determined by microarray method. In the
progression to PCA, 738 up-regulated and 515 downregulated
genes were detected in samples. Analysis
using Ingenuity Pathway Analysis (IPA) software revealed
that 466 network and 423 functions-pathways
eligible genes were up-regulated, and 363 network and
342 functions-pathways eligible genes were down-regulated.
Up-regulated networks were identified
around IL-1β and insulin-like growth factor-1 (IGF-1)
genes. The NFKB gene was centered around two upand
down-regulated networks. Up-regulated canonical
pathways were assigned and four of them were
evaluated in detail: acute phase response, hepatic fibrosis,
actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant
down-regulated canonical pathway. Our data provide
not only networks between the genes for understanding
the biologic properties of PCA but also useful pathway
maps for future understanding of disease and the construction
of new therapeutic targets.
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참고문헌 (25)
참고문헌 신청
Abate-Shen C / 2000 / Molecular genetics of prostate cancer / Genes Dev 14 : 2410 ~ 34
Akashi T / 2006 / Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in PCA DU-145 / Oncol Rep 16 : 831
Akdogan M / 2002 / Prostate-specific antigen levels among cirrhotic patients / Int J Biol Markers 17 : 161 ~ 4
Albrecht M / 2004 / Proliferation of PCA cells and activity of neutral endopeptidase is regulated by bombesin and IL- 1beta with IL-1beta acting as a modulator of cellular di
Ao M / 2007 / Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium / Cancer Res 67 : 4244 ~ 53
Akashi T / 2006 / Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in PCA DU-145 / Oncol Rep 16 : 831
Akdogan M / 2002 / Prostate-specific antigen levels among cirrhotic patients / Int J Biol Markers 17 : 161 ~ 4
Albrecht M / 2004 / Proliferation of PCA cells and activity of neutral endopeptidase is regulated by bombesin and IL- 1beta with IL-1beta acting as a modulator of cellular di
Ao M / 2007 / Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium / Cancer Res 67 : 4244 ~ 53
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