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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 180 - 189 (10page)
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In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 trans-location have been demonstrated; however, the mechanism of action of Ca2+ in this process is unknown. Recently, myosin II, whose function in non-muscle cells is primarily regulated by phos-phorylation of its regulatory light chain by the Ca2+/calmodulin-dependent myosin light chain ki-nase (MLCK), was implicated in insulin-stimulated GLUT4 translocation. The present studies in 3T3- F442A adipocytes demonstrate the novel finding that insulin significantly increases phosphorylation of the myosin II RLC in a Ca2+addition, ML-7, a selective inhibitor of MLCK, as well as inhibitors of myosin II, such as blebbistatin and 2,3-butanedione monoxime, block insulin- stimul-ated GLUT4 translocation and subsequent glucose transport. Our studies suggest that MLCK may be a regulatory target of Ca2+/calmodulin and may play an important role in insulin-stimulated glucose trans-port in adipocytes.
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참고문헌 (27)
참고문헌 신청
[학술
/ / Trifluoperazine inhibits insulin action glucose metabolism in fat cells without MLCK in insulin-stimulated GLUT4 translocation 189Proc Natl Acad Sci U S A 1984 : 327 ~
/ 1978 / Adipose conversion of 3T3 cells depends on a serum factor 75 : 6107 ~ 9
/ 1980 / New calcium indicators and bufers with high selectivity against magnesium and protons:design,syn-thesis,and properties of prototype structures 19 : 2396 ~ 404
/ 1987 / Cytoplasmic Ca2+ during diferentiation of 3T3-L1 adipocytes.Effect of insulin and relation to glucose transport 262 : 9141 ~ 6
/ / Trifluoperazine inhibits insulin action glucose metabolism in fat cells without MLCK in insulin-stimulated GLUT4 translocation 189Proc Natl Acad Sci U S A 1984 : 327 ~
/ 1978 / Adipose conversion of 3T3 cells depends on a serum factor 75 : 6107 ~ 9
/ 1980 / New calcium indicators and bufers with high selectivity against magnesium and protons:design,syn-thesis,and properties of prototype structures 19 : 2396 ~ 404
/ 1987 / Cytoplasmic Ca2+ during diferentiation of 3T3-L1 adipocytes.Effect of insulin and relation to glucose transport 262 : 9141 ~ 6
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