지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 189 - 200 (12page)
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초록· 키워드
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Objectives :The purpose of this study is to examine the effects of antioxidant activities and serotonin activities of OnDam-tang- Kami-bang (ODK) on P815 Mast Cell.
Methods :The effects of ODK on the activation of DPPH radical‐scavenging and SOD in P815 mast cell were investigated. The effect of ODK on the content of serotonin in P815 mast cell was investigated. The effects of ODK on the activation of 5-HTT, TPH-1 mRNA in P815 mast cell were investigated.
Results :It was found that the ODK increased SOD activities and DPPH radical‐scavenging activities in the P815 mast cell. Also, the ODK decreased the intracellular concentration of serotonin in the P815 mast cell. Further, the ODK decreased 5-HTT and TPH-1 mRNA expression in the P815 mast cell.
Conclusions :The results of this experiment reveal that ODK has significant antioxidative effects. However, ODK decreased the intracellular concentration of serotonin and mRNA expression of 5-HTT and TPH-1, which implies that ODK might not be effective for treating depression. Further research exploring the positive aspects of ODK is suggested such that ODK could adequately target symptoms that are to be treated.
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참고문헌 (28)
참고문헌 신청
Adham N / 1993 / Cell-specific Coupling of the Cloned Human 5-HT1F Receptor to Multiple Signal Transduction Pathways / Naunyn-Schmiedeberg's Archi Pharmacol 348 (6) : 566 ~ 5
Choi YM / 1996 / Effects of Perceived Stress and Ways of Coping on Anxiety and Depression in the White-collars / J Korean Neuropsychiatr Assoc 35 (6) : 1376 ~ 1385
Eom SH / 1983 / Experimental Study on the Effect of the Administration of Gamiondamtang on the Sleep Time / 석사 / Graduate School of Kyunghee University
Heo J / 2005 / Dong ui bo gam / Beob-in munhwasa : 303 ~ 428
Hoyer D / 1994 / International Union of Pharmacology Classification of Receptors for 5-hydroxytryptamine (Serotonin) / Pharmacol Rev 46 (2) : 157 ~ 203
Choi YM / 1996 / Effects of Perceived Stress and Ways of Coping on Anxiety and Depression in the White-collars / J Korean Neuropsychiatr Assoc 35 (6) : 1376 ~ 1385
Eom SH / 1983 / Experimental Study on the Effect of the Administration of Gamiondamtang on the Sleep Time / 석사 / Graduate School of Kyunghee University
Heo J / 2005 / Dong ui bo gam / Beob-in munhwasa : 303 ~ 428
Hoyer D / 1994 / International Union of Pharmacology Classification of Receptors for 5-hydroxytryptamine (Serotonin) / Pharmacol Rev 46 (2) : 157 ~ 203
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