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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한한방신경정신과학회 동의신경정신과학회지 동의신경정신과학회지 제22권 제4호
발행연도
2011.1
수록면
201 - 219 (19page)

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Objectives :The aim of this study was to investigate the effects of Guibi-Tang(GBT) on focal brain ischemic injury induced by intraluminal filament insertion in rats. Methods :The ischemia was induced by intraluminal filament insertion into middle cerebral artery. Sprague-Dawley rats were divided into five groups, normal group(n=8); control group was ischemia induced and no treatment(n=8); GBT 1X group was ischemia induced and administrated 42.2 mg/ml/kg of Guibi-Tang orally(n=8); GBT 3X group was ischemia induced and administrated 126.6 mg/ml/kg of Guibi-Tang orally(n=8); GBT 6X group was ischemia induced and administrated 253.2 mg/ml/kg of Guibi-Tang orally(n=8) for 21 days. mGluR5, Bax, Bcl-2 and cytochrome C were investigated to observe the effects of Guibi-Tang on apoptosis. The effects of Guibi-Tang on neuroprotective/apoptotic agents in cresyl violet, choline acetyltranferase(ChAT) with ischemic injury were investigated. Results :The intensity of mGluR5 mRNA in the hippocampal CA1 was increased in normal and GBT(Guibi-Tang) 1X groups compared with the control group. The intensity of Bax mRNA in the hippocampal CA1 was decreased in normal and GBT 1X groups compared with the control group. However it was increased unexpectedly in GBT 3X group. The intensity of Bcl-2 mRNA in the hippocampal CA1 was increased in normal and GBT 1X groups compared with the control group. The intensity of Bax/Bcl-2 ratio in the hippocampal CA1 was decreased in normal and GBT 1X groups compared with the control group. The intensity of cytochrome C protein in the hippocampal CA1 was decreased in normal, GBT 1X and GBT 6X groups compared with the control group. The density of neurons stained by cresyl violet and ChAT was increased in normal and GBT 1X groups compared with the control group. Conclusions :These results suggest that Guibi-Tang may have protective effect on vascular dementia.
#Guibi-Tang #herb #vascular dementia #ischemic injury #intraluminal filament insertion

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참고문헌 (33)

참고문헌 신청
Choi DW / 1996 / Ischemia-induced neuronal apoptosis / Curr Opin Neurobiology 6 : 667 ~ 672 google schola Fujusawa A / 1986 / The effect of the calcium antagonist nimodipine on the gerbil model of experimental cerebral ischemia / Stroke 17 : 748 ~ 752 google schola Gill R / 1998 / MK-801 is neuroprotective in gerbils when administered during the post-ischemic period / Neuroscience 25 : 254 ~ 855 google schola Hall ED / 1997 / Tzke BS et al. Pyrrolopyrimidines:novel brain-penetration antioxidants with neuroprotective activity in brain injury and ishcemia models / J Pharmacol Exp T google schola Kirino T / 1985 / Selective vulnerability of the hippocampus to ischemia -reversible and irreversible types of ischemic cell damage / Progress in Brain Res 63 : 39 ~ 58 google schola

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