혈청 대사체와 뇌졸중 발생위험의 용량반응 분석

지연호; 정금지; 임연희; 이예승; 박영자; 지선하

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자료유형: 학술저널

저자정보: 지연호 정금지 임연희 이예승 박영자 지선하

저널정보: 한국보건정보통계학회 보건정보통계학회지 보건정보통계학회지 제41권 제3호

발행연도: 2016.1

수록면: 318 - 323 (6page)

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Objectives: Except the known risk factors for stroke, few studies have identified novel metabolic markers that could effectively detect stroke at an early stage. In this study, we explored the dose-response relationship between serum metabolites and the incidence of stroke. Methods: We studied 213 adults in the Korean Cancer Prevention Study-II (KCPS-II) biobank and estimated dose-response relationship between serum metabolites and stroke (42 cases and 171 controls). Three serum metabolites (Acetylcholine, HexadecylAcetylGlycerol, and 1-acetyl-2-formyl-sn-glycero-3-phosphocholine) were used in this study. The analysis included (1) exploratory nonlinear analysis, (2) estimation of flexion points and slopes at below and above the points. In the model to estimate risk of incidence of stroke, we controlled for conventional risk factors such as age, sex, systolic blood pressure, type 2 diabetes, triglyceride, and smoking status. Results: The relationship between incidence of stroke and log-transformed 1-acetyl-2-formyl-sn-glycero-3-phosphocholine was non-linear with flexion point around intensity score of 8.8, whereas other metabolites, log-transformed Acetylcholine and HexadecylAcetylGlycerol, showed negative linear patterns. Conclusions: The study suggests that metabolic markers are associated with incidence of stroke, particularly, at or above the flexion point. The study result may contribute to developing a novel system for precise stroke prediction.

#Cohort study #Dose-response #Metabolites #Stroke

참고문헌 (20)

참고문헌 신청

World Health Organization / Fact sheet on cardiovascular diseases

Statistics Korea / 2013 / 2012 Annual report on the causes of death statistics

Jee SH / 1999 / Smoking and atherosclerotic cardiovascular disease in men with low levels of serum cholesterol: the Korea Medical Insurance Corporation Study / JAMA 282(22):2149~2155

Del Gobbo LC / 2015 / Contribution of major lifestyle risk factors for incident heart failure in older adults: the Cardiovascular Health Study / JACC Heart Fail 3(7):520~528

Ho JE / 2016 / Metabolomic profiles of body mass index in the framingham heart study reveal distinct cardiometabolic phenotypes / PLoS One 11(2):e0148361

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