지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 123 - 129 (7page)
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초록· 키워드
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Objectives :During several thousand years, Peucedanum Japonicum Thunberg has been considered as a vegetable side dish in Korea. There is folk knowledge that Peucedanum Japonicum Thunberg prevents vascular disease such as stroke. To identify the effects Peucedanum Japonicum Thunberg, we made up its extract and named it as KH020. Then, we employed common carotid artery ligation (CCAl) surgery for vascular dementia model (VDM), and two types doses of per os (per oral: p.o) treatment.
Methods :To confirm prevention and recovery effects for vascular dementia, we treated two doses (100, 400 mg/kg) KH020 in male C57BL/6 mouse during 7 days. After treatment, animals were CCAl operated, and given time to recover. Then, animal were tested in a Y-maze and passive avoidance test.
Results :Y-maze results demonstrated that cognition and memory performance were decreased in the VDM group, compared to the sham group. KH020 treatment abolished these effects significantly. The results from the passive avoidance test showed the same phenomenon, but it was not statically significant.
Conclusions :Therefore, KH020 prevents the onset of vascular dementia. In future studies, we will evaluate KH020 in regard to alzheimer dementia.
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참고문헌 (13)
참고문헌 신청
Aerden LA / 2004 / Diazepam Reduces Brain Lesion Size in a Photothrombotic Model of Focal Ischemia in Rats / Neurosci Lett 367 : 76 ~ 78
Chen, IS / 1996 / Coumarins and Antiplatelet Aggregation Constituents from Formosan Peucedanum japonicum / Phytochemistry 41 : 525 ~ 530
Dubois MF / 2001 / The Incidence of Vascular Dementia in Canada: A Comparisonwith Europe and East Asia / Neuroepidemiology 20 : 179 ~ 187
Gorelick PB / 2011 / Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals from the American Heart Association/ American Strok
Hisamoto M / 2003 / Antioxidant Compounds from the Leaves of Pescedanum Japonicum Thunb / J Agric Food Chem 51 : 5255 ~ 5261
Chen, IS / 1996 / Coumarins and Antiplatelet Aggregation Constituents from Formosan Peucedanum japonicum / Phytochemistry 41 : 525 ~ 530
Dubois MF / 2001 / The Incidence of Vascular Dementia in Canada: A Comparisonwith Europe and East Asia / Neuroepidemiology 20 : 179 ~ 187
Gorelick PB / 2011 / Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals from the American Heart Association/ American Strok
Hisamoto M / 2003 / Antioxidant Compounds from the Leaves of Pescedanum Japonicum Thunb / J Agric Food Chem 51 : 5255 ~ 5261
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