지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 143 - 160 (18page)
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초록· 키워드
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Objectives :To provide information on the safety of ACM, we carried out a 13-week repeated oral dose toxicity and a 4-week recovery test of ACM in Sprague-Dawley rats.
Methods :Female and male rats were treated with ACM with oral doses of 800, 2000, and 5000 ㎎/㎏. The ACM was administered for 13 weeks. Mortality, clinical signs, body weight changes, food consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers were monitored during the study period. Moreover, the rats were monitored for 4 extra weeks to determine recovery time after the study period.
Results :We found no mortality and no abnormalities in clinical signs, body weight, food consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers in any of the rats tested.
Conclusions :The no-observed adverse effects level (NOAEL) was considered as over 5000 mg/kg for male and female rats.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Byeon YC / 1997 / The mapping development research of dementia management
Chae JG / 2002 / BR(CPVM)extract on the the Alzheimer's disease model induced by CT105 / Journal of oriental neuropsychiatry 13 (1) : 79 ~ 115
Cheng / 2000 / A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer’ disease / Nature 408 : 975 ~ 979
Cheong MH / 2011 / Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappa B activation in lipopolysaccharide-induced BV2 microglial cells / JOU
Citron M / 1996 / Evidence that the 42-and 40-amino acid forms of amyloid beta protein aregenerated from the beta-amyloid precursor protein by different protease activities / Proc
Chae JG / 2002 / BR(CPVM)extract on the the Alzheimer's disease model induced by CT105 / Journal of oriental neuropsychiatry 13 (1) : 79 ~ 115
Cheng / 2000 / A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer’ disease / Nature 408 : 975 ~ 979
Cheong MH / 2011 / Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappa B activation in lipopolysaccharide-induced BV2 microglial cells / JOU
Citron M / 1996 / Evidence that the 42-and 40-amino acid forms of amyloid beta protein aregenerated from the beta-amyloid precursor protein by different protease activities / Proc
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