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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국피부과학연구원 아시안뷰티화장품학술지 아시안뷰티화장품학술지 제10권 제1호
발행연도
2012.1
수록면
91 - 97 (7page)

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The purpose of this study is to investigate the influence of black ginseng (BG) on induced IL-6, IL-8 and MCP-1 secretion by house dust mite in THP-1 (human acute monocytic leukemia cell line) and EoL-1 (human eosinophilic leukemic cells) cell lines. The house dust mite (Dermatophagoides pteronissinus, D. pteronissinus )plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemoattractant protein 1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) play a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. The korean ginseng (radix and leaf) was steamed to 3 hr at 120℃ under high pressure. The contents of benzopyrene which was known as a tumor promoting agent were analysed. Also, the inhibitory effect of BG on the induced IL-6, IL-8 and MCP-1 secretion by D. pteronissinus extract (DpE) in THP-1 and MCP-1 cells was examined. The BG extract (radix and leaf) potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in THP-1 and EoL-1 cells. Among them, the crude saponin fraction of BG leaf exhibited the most potent inhibitory activity. Based on the present results, it can be suggested that the 3 hr steaming at 120℃ under high pressure is the most optimal processing condition and BG may be useful to develop functional food on atopic dermatitis.

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