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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국피부과학연구원 아시안뷰티화장품학술지 아시안뷰티화장품학술지 제13권 제6호
발행연도
2015.1
수록면
735 - 742 (8page)

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This study conducted cytotoxicity and anti-inflammatory tests on Lespedeza cuneata extract. The study results found the followings: RAW 264.7 cells’ viability was 78%. The inhibition of production was as high as 84% at 25 ㎍/mL. It wasn’t able to confirm decrease in cytokine in pro-inflammatory mediators such as iNOS, IL- 1β and IL-6. In a protein kinase inhibition test, however, p-JNK was slightly suppressed at high concentration while p-ERK was inhibited at both low and high concentrations. Based on the results of this anti-inflammatory test, scalp tonic was produced with Lespedeza cuneata . Then, keratin, microbial biomass, erythema dose and image analyses were conducted against adult men (in their 30~40s) suffering from a scalp problem after dividing them into a control group (11 people), Lespedeza cuneata -added scalp tonic group (“T” group, 11 people) and ‘Lespedeza cuneata -added scalp tonic+scalp cleansing’ group (“TC” group, 11 people) for four weeks. First, in terms of keratin, no significant change was found in a control group while it significantly declined in T group (by 50.3%) and TC group (58.5%). In microorganism as well, no significant difference was observed in a control group. It slightly decreased in T group (63.8%, p=.066) while a significant decrease was detected in TC group (74.5%). In changes in erythema, T and TC groups decreased by 36.6% and 38.9% respectively with statistical significance. In image analysis as well, no significant difference was found in a control group while improvement of erythema was detected in both T and TC groups. Compared to a control group, therefore, scalp improvement effects were observed in T and TC groups. The anti-inflammatory effects of Lespedeza cuneata were verified. According to the said results, it appears that Lespedeza cuneata extract is considerably valuable as the material of scalp cosmetics.

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