지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 921 - 928 (8page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to investigate whitening effect of 4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3 (2H)-furanone (HEMF). The antioxidant activity of HEMF was evaluated using in vitro 1,1-diphenyl-2-picrylhydrazy (DPPH) free radical assay. Inhibitory effects of HEMF against tyrosinase activity and melanogenesis in B16 melanoma cells were assessed in vitro to determine whitening effect. HEMF showed strong radical scavenging activity in DPPH assay. The SC50 (concentration that inhibits 50% of the DPPH radical) values of HEMF was 1.5 mg/L. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with B16 melanoma cells showed that HEMF was not toxic up to the concentration of 1000 mg/L. HEMF induced dose-dependent inhibition of mushroom tyrosinase activity showing 71% inhibition at a concentration of 250 mg/L. Various concentrations (2.5-50 mg/L) of HEMF also significantly inhibited tyrosinase activity in B16 melanoma cells by 20-65 %. In addition, HEMF significantly reduced melanin contents of B16 melanoma cells by 52 % at a concentration of 50 mg/L. These results suggest that HEMF could be an effective whitening agent.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Blank I / 1993 / Analysis of the seasoning-like flavour substances of a commercial lovage extract (Levisticum officinale Koch) / Flavour Fragrance J 8 : 191 ~ 195
Blank I / 1996 / Formation of 4-Hydroxy-2,5- dimethyl-3 (2H)-furanone and 4-Hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3 (2H)-furanone through Maillard Reaction Based on Pentose
Cerny C / 1992 / Evaluation of the potent odorants in roasted beef by aroma extract dilution analysis / Z. Lebensm. Unters. Forsch 194 : 322 ~ 325
EK Bernadette / 1998 / Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and α-tocopherol (vitamin E) / J. Am. Acad.Dermatol 38 : 45 ~ 48
Englaro W / 1995 / Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells / J. Biol. Chem 270 : 24315 ~
Blank I / 1996 / Formation of 4-Hydroxy-2,5- dimethyl-3 (2H)-furanone and 4-Hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3 (2H)-furanone through Maillard Reaction Based on Pentose
Cerny C / 1992 / Evaluation of the potent odorants in roasted beef by aroma extract dilution analysis / Z. Lebensm. Unters. Forsch 194 : 322 ~ 325
EK Bernadette / 1998 / Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and α-tocopherol (vitamin E) / J. Am. Acad.Dermatol 38 : 45 ~ 48
Englaro W / 1995 / Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells / J. Biol. Chem 270 : 24315 ~
이 논문의 저자 정보
최근 본 자료
댓글(0)
0