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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 961 - 968 (8page)
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초록· 키워드
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Reynoutria elliptica is Asian as traditional herbal medication. In this study, we examined the Inhibition of melanogensis and anti-UV properties ethanol extract of R. elliptica. Total polyphenols and flavonoids contents of R. elliptica, the result was respectively 209.2±1.2, 83.4±2.0 mg/g. Electron-donating ability of ethanol extract of R. elliptica was in 400 ㎍/㎖ as 92.92±1.51%. Tyrosinase have suppress effect in a dose dependent. UVblocking effect was also showed a strong UV absorption in the range of UV-A(350-370 ㎚). In addition we tested tyrosinase inhibition activity and melanin contents on SK-MEL-2. Tyrosinase was inhibited to 40% at the dose of 20 ㎍/㎖ and melanogenesis was inhibited was 30%. Overall, our results indicate that R.elliptica extract showed that the α-MSH-mediated upregulation of tyrosinase activity and melanogenesis were inhibited in the extract does dependent manner in Sk-MEL-2 cells. Hence, R. elliptica extract could be applied as a type of dermatological whitening and anti-UV agent in skin care products.
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참고문헌 (34)
참고문헌 신청
Blois MS / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 26 : 1199 ~ 1200
Gray JI / 1975 / Inhibition of N-nitrosamine formationin model food system / J. Food Sci 40 : 981 ~ 984
Gutfinger / 1981 / Polyphenols in olive olis / J. Am. Oil Chem. Soc 58 : 966 ~ 968
Hosoi J / 1985 / Regulation of melanin synthesis of B16 mous melanoma cells by 1 α , 25-Dihydroxyvitamin D3 and Retinoic Acid / Cancer Res 45 : 1474 ~ 1478
Martinez-Esparza M / 1998 / Garcia-Borron JC, Mechanism of melanogenesis inhibition by tumor necrosis factoralpha in B16/F10 mouse melanoma cells / Eur. J. Biochem 255 : 139
Gray JI / 1975 / Inhibition of N-nitrosamine formationin model food system / J. Food Sci 40 : 981 ~ 984
Gutfinger / 1981 / Polyphenols in olive olis / J. Am. Oil Chem. Soc 58 : 966 ~ 968
Hosoi J / 1985 / Regulation of melanin synthesis of B16 mous melanoma cells by 1 α , 25-Dihydroxyvitamin D3 and Retinoic Acid / Cancer Res 45 : 1474 ~ 1478
Martinez-Esparza M / 1998 / Garcia-Borron JC, Mechanism of melanogenesis inhibition by tumor necrosis factoralpha in B16/F10 mouse melanoma cells / Eur. J. Biochem 255 : 139
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