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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 891 - 897 (7page)
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초록· 키워드
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Kojic acid is a fungal metabolite widely used in medicinal and cosmetic formulations as a skin whiteningagent. The activity of kojic acid is known to arise primarily from suppressing tyrosinase activity. Althoughkojic acid is effective in treating hyperpigmentation disorders in human clinical studies, it only shows weakantimelanogenic activity in mono-cultured human primary melanocytes, suggesting that there exists anotherpharmacological mechanism for in vivo activity of kojic acid. In the present study, we used primary humanepidermal melanocytes and keratinocytes co-culture system to elucidate the mechanisms of skin whiteningactivity of kojic acid. We used a newly developed flow cytometric method to analyze the counts of livemelanocytes and keratinocytes separately. When cultured without kojic acid, the proliferation of melanocytesco-cultured with keratinocytes was greatly enhanced compared to that of mono-cultured melanocytes. Onthe other hand, we found that kojic acid significantly reduced the proliferation of both melanocytes andkeratinocytes at 100~200 μM in co-culture system, although kojic acid did not reduce the proliferation ofmono-cultured melanocytes nor mono-cultured keratinocytes at the same concentration. These resultssuggest that kojic acid might suppress the expression of some growth factors produced by melanocytesor keratinocytes in co-culture system, resulting in reduced proliferation of melanocytes. In summary, themechanisms of the clinical skin whitening activity of kojic acid might include the suppression of melanocyteproliferation as well as the already known activity of tyrosinase suppression. It suggests that a cross-talkbetween melanocytes and keratinocytes is indispensable to the pharmacological mechanisms of clinicallyeffective dermatological drugs.
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참고문헌 (24)
참고문헌 신청
Abdel-Naser MB. / 1999 / Differential effects on melanocyte growth and melanization of low vs. high calcium keratinocyte-conditioned medium / Br. J. Dermatol 140 : 50 ~ 55
Boxman I / 1993 / Modulation of IL-6 production and IL-1 activity by keratinocytefibroblast interaction / J. Invest. Dermatol 101 : 316 ~ 324
Bronner-Fraser M. / 1985 / Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion / J . Cell. Biol 101 : 610 ~ 617
Burdock GA / 2001 / Evaluation of health aspects of kojic acid in food / Regul. Toxicol. Pharmacol 33 : 80 ~ 101
Choi H / 2005 / Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6mediated signaling / Pigment Cell Res 18 : 439 ~ 446
Boxman I / 1993 / Modulation of IL-6 production and IL-1 activity by keratinocytefibroblast interaction / J. Invest. Dermatol 101 : 316 ~ 324
Bronner-Fraser M. / 1985 / Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion / J . Cell. Biol 101 : 610 ~ 617
Burdock GA / 2001 / Evaluation of health aspects of kojic acid in food / Regul. Toxicol. Pharmacol 33 : 80 ~ 101
Choi H / 2005 / Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6mediated signaling / Pigment Cell Res 18 : 439 ~ 446
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