지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 675 - 684 (10page)
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초록· 키워드
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In this study, we investigated effects of the complex material containing Centella asiatica (C. asiatica )- and folic acidfermented extracts, acetyl glutamine, and nicotinic acid adenine dinucleotide phosphate (NAADP) on the improvement of skin condition and skin cell functions. We confirmed cellular effects of fermented extracts of C. asiatica and folic acid using microorganism mixture (CFFE) and acetyl glutamine- and NAADP-containing CFFE (FAN) on cell viability, reactive oxygen species (ROS) generation, cellular senescence, DNA repair, transcriptional activity of NF-κB, regulation of gene expression, cellular regeneration and migration, cell differentiation, and melanin contents in human dermal fibroblasts (HDFs), HaCaT human keratinocytes, B16F10 mouse melanocytes, and NIH-3T3 mouse embryo fibroblasts. CFFE and FAN showed significant protection effects against cellular damage caused by ultraviolet B (UVB) irradiation or ROS generation. The expression levels of Col1A1 was up-regulated and of MMP1 was down-regulated by treatment of CFFE and FAN in UVB-exposed HDFs. UVB-induced NF-κB activation was significantly suppressed by treatment of CFFE and FAN in NIH-3T3 cells. Also the treatment of CFFE and FAN promoted the differentiation on HaCaT cells. The CFFE and FAN suppressed production of melanin in B16F10 cells by inhibition of expression of MITF and TYR. Especially, it was observed that acetyl glutamine and NAADP increase overall effects of CFFE in earlier time points, implicating that these components initiate and boost cellular signals and positive functions mediated by CFFE in the skin. Taken together, these findings suggest that CFFE and FAN might have excellent efects of the anti-aging, reduction of wrinkle and pigmentation, promotion of cellular regeneration, improvement of epidermal barrier quality, and anti-inflammation on the skin cell.
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참고문헌 (29)
참고문헌 신청
[학술지(
An IS / 2012 / Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes / Int. J. Mol. Med 30 : 1349 ~ 1356
An IS / 2012 / Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts / Int. J. Mol. Med
Archambault J / 2002 / Stretch and interleukin-1beta induce matrix metalloproteinases in rabbit tendon cells in vitro / J. Orthop. Res 20 : 36 ~ 39
Arnaud A / 2004 / Absorption of enterally administered N-acetyl-L-glutamine versus glutamine in pigs / Clin. Nutr 23 : 1303 ~ 1312
An IS / 2012 / Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes / Int. J. Mol. Med 30 : 1349 ~ 1356
An IS / 2012 / Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts / Int. J. Mol. Med
Archambault J / 2002 / Stretch and interleukin-1beta induce matrix metalloproteinases in rabbit tendon cells in vitro / J. Orthop. Res 20 : 36 ~ 39
Arnaud A / 2004 / Absorption of enterally administered N-acetyl-L-glutamine versus glutamine in pigs / Clin. Nutr 23 : 1303 ~ 1312
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