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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 471 - 478 (8page)
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초록· 키워드
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This study observed the effects of Ephedra sinica (E. sinica ) ethanol extract in SK-MEL-2 cells ontyrosinase activity and melanin generation to identify its whitening activity and searched for changes inthe protein expression of tyrosinase, TRP-1 and TRP-2 which are involved in melanin synthesis. Also,α-MSH, a melanin-stimulating enzyme was applied to skin to induce hyperpigmentation and to identifythe skin whitening effect. The following results were obtained. As a result of measuring its tyrosinaseinhibitory activity in vitro , it showed good inhibitory rates depending on concentration. When its effect ontyrosinase activity and melanin generation in SK-MEL-2 cell was analysed, tyrosinase activity decreased ata concentration of 50 ㎍/mL and with arbutin at 82.2%, and tyrosinase activity decreased 70.4% in E. sinicaethanol extract. As a result of measuring melanin generation, arbutin was inhibited 83.6% in 50 ㎍/mL ,and 64% of E. sinica ethanol extract inhibited melanin. In investigating the effect of tyrosinase, TRP-1 andTRP-2 on protein expression in hyperpigmentation by α-MSH using western blot, E. sinica ethanol extractmade the expression of tyrosinase and TRP2 decrease more significantly than arbutin. Therefore, E. sinicaethanol extract showed good effects in inhibiting tyrosinase activity and melanin generation in SK-MEL-2cells, and inhibited melanin synthesis through inhibition of gene expression. Also, it effectively decreasedthe generation of tyrosinase and melanin increased by α-MSH. Based on the results above, it is suggestedthat E. sinica can be developed as a natural skin care material for use in whitening.
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참고문헌 (33)
참고문헌 신청
Dawley RM / 1993 / 4-hexylresocinol a potent inhibitor of mushroom tyrosinase. / J. Food Sci 58 : 609 ~ 616
Dullo AG / 1991 / Peripheral mechanism of thermogenesis induced by ephedrine and caffeine in brown adipose tissue / Int. J. Obes 15 : 317 ~ 326
Duncan PE / 1957 / Bronchodilator drug efficacy via cyclic AMP / Thorax 30 : 192 ~ 196
Friedman PS / 1990 / α-MSH causes a small rise in cAMP but has no effect on basa l or ultraviolet-stimulated melanogenesis in human melanocytes / Br. J. Dermatol 123 : 145
Funasaka Y / 1999 / The depogmenting effect of alpha tocophenyl ferulate on human melanoma cells / Br. J. Der 141 : 20 ~ 29
Dullo AG / 1991 / Peripheral mechanism of thermogenesis induced by ephedrine and caffeine in brown adipose tissue / Int. J. Obes 15 : 317 ~ 326
Duncan PE / 1957 / Bronchodilator drug efficacy via cyclic AMP / Thorax 30 : 192 ~ 196
Friedman PS / 1990 / α-MSH causes a small rise in cAMP but has no effect on basa l or ultraviolet-stimulated melanogenesis in human melanocytes / Br. J. Dermatol 123 : 145
Funasaka Y / 1999 / The depogmenting effect of alpha tocophenyl ferulate on human melanoma cells / Br. J. Der 141 : 20 ~ 29
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