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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 239 - 252 (14page)
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이 논문의 연구 히스토리 (4)
2014
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Chronic ultraviolet-B (UVB) irradiation of the skin results in epidermal hyperplasia, degradation of extracellular matrix, and formation of wrinkles. To investigate the anti-photoaging effect of extract of Yukmijiwhangtang (YM) in SKH-1 mice. We observed the effects of YM on skin wrinkles formation, histological changes related to epidermal thickness, collagen fibers, elastic fibers and mast cells, and immunohistochemical changes related to cytokines and enzymes in photoaging skin caused by UVB irradiation of SKH-1 mice. The oral administration YM-O and topical application of extract of YM (YM-OA) significantly decreased wrinkle formation and the epidermal thickness compared to control group (p<.01). Furthermore, YM-OA prevented the disruption of collagen fibers within papillary layer of dermis, and significantly decreased number of mast cells in the dorsal and ear skins induced by UVB irradiation (p<.05). Treatment with YM-O and YM-OA decreased immunohistochemical density of matrix metalloproteinases (MMP)-2, -3 related to degradation of extracellular matrix, and vascular endothelial growth factor (VEGF) expression related to angiogenesis in the epidermis. Treatment with YM-O and YM-OA reduced number of epidermal growth factor (EGF) immunostained cells related to activation of MAP kinase pathways involving upregulation of EGF receptor in the photoaging skin. Our study suggests that oral administration and topical application of Yukmijiwhangtang participates in inhibitory effects in the process of photoaging skin on UVB irradiated SKH-1 mice.
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참고문헌 (29)
참고문헌 신청
Berneburg M / 2000 / Photoaging of human skin / Photodermatol. Photoimmunol. Photomed 16 : 239 ~ 244
Bernstein EF / 1996 / Longterm sun exposure alters the collagen of the papillary dermis: comparison of sun-protected and photoaged skin by Northern analysis, immunohistochem
Bhawan J / 1992 / Histopathologic differences in the photoaging process in facial versus arm skin / Am. J. Dermatopathol 14 : 224 ~ 230
Birkedal-Hansen H / 1995 / Proteolytic remodeling of extracellular matrix / Curr. Opin. Cell Biol 7 : 728 ~ 735
Brenneisen P / 1997 / Hydrogen peroxide(H2O2) increases the steady mRNA leves of collagenase/MMP-1 in human dermal fibroblasts / Free Radic. Biol. Med 22 : 515 ~ 524
Bernstein EF / 1996 / Longterm sun exposure alters the collagen of the papillary dermis: comparison of sun-protected and photoaged skin by Northern analysis, immunohistochem
Bhawan J / 1992 / Histopathologic differences in the photoaging process in facial versus arm skin / Am. J. Dermatopathol 14 : 224 ~ 230
Birkedal-Hansen H / 1995 / Proteolytic remodeling of extracellular matrix / Curr. Opin. Cell Biol 7 : 728 ~ 735
Brenneisen P / 1997 / Hydrogen peroxide(H2O2) increases the steady mRNA leves of collagenase/MMP-1 in human dermal fibroblasts / Free Radic. Biol. Med 22 : 515 ~ 524
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