지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 733 - 743 (11page)
이용수
초록· 키워드
오류제보하기
Animal-derived placenta extract (PE) are available commercially and regularly used in various ointmentsand lotions for the purpose of improving skin properties. Although the effects of PE have been largelystudied, only a few scientific studies report the skin safety evaluations of PE derived from animals such aspig. The objective of this study was to evaluated the anti-aging potential and safety of collagen in subcriticalextract of porcine homogenate of placenta (SPE) for nutricosmetic and cosmeceutical ingredients. Theexperimental animals were divided into 6 groups, and were treated for 12 wks: positive control group (PO)treated with no-ultra violet (UV)B, negative control group (NO) treated with only UVB, experimental group1 (OSPE-1) low dosage oral application treated with SPE, experimental group 2 (OSPE-2) high dosageoral application treated with SPE, experimental group 3 (OSPE-1+FSPE-1) low dosage oral and topicalapplication treated with SPE, and experimental group 4 (OSPE-2+FSPE-2) high dosage oral and topicalapplication treated with SPE. The serum biochemical markers for liver, aspartate aminotransferase (AST),and alanine aminotransferase (ALT) were also not affected by the application of SPE at any groups. ButOSPE-2+FSPE-2 had significant (p<.05) decreased in lactate dehydrogenase (LDH) level compared thanNO. The skin safety was performed to evaluate of potential toxicity using the primary irritation test andskin sensitization test. The SPE did not show any adverse reactions such as erythema and edema onintact skin sites at primary irritation test, but on abraded sites, some experimental animals showed veryslight erythema. So, the SPE was classified as a practically non-irritating material based on the score 0.48of primary irritation index. The skin sensitization study was tested by the guinea pig maximization test(GPMT) and Freund’s complete adjuvant (FCA) with intradermal injection of SPE. The skin sensitization testshowed no skin sensitization. Based on this study, the potential for SPE a nutricosmetic and cosmeceuticalingredients were proven.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Biasi F / 1991 / In vivo and in vitro evidence concerning the role of lipid peroxidation in the mechanism of hepatocyte death due to carbon tetrachloride / Cell Biochem. Fun
Biswas TK / 2001 / Wound healing activity of human placental extracts in rats / Acta. Pharmacol. Sin 22 : 1113 ~ 1136
Cross JC. / 2006 / Placental function in development and disease / Reprod. Fertil. Dev 18 : 71 ~ 76
Draize JH / 1944 / Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes / J. Pharmacol. Exp. Ther 82 : 377 ~ 390
Ferger B / 2000 / The protective effects of PBN against MPTP toxicity are independent of hydroxyl radical trapping / Phamacol. Biochem. Behav 65 : 425 ~ 431
Biswas TK / 2001 / Wound healing activity of human placental extracts in rats / Acta. Pharmacol. Sin 22 : 1113 ~ 1136
Cross JC. / 2006 / Placental function in development and disease / Reprod. Fertil. Dev 18 : 71 ~ 76
Draize JH / 1944 / Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes / J. Pharmacol. Exp. Ther 82 : 377 ~ 390
Ferger B / 2000 / The protective effects of PBN against MPTP toxicity are independent of hydroxyl radical trapping / Phamacol. Biochem. Behav 65 : 425 ~ 431
이 논문의 저자 정보
최근 본 자료
댓글(0)
0