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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Radiotherapy is a crucial non-surgical modality for head and neck cancer. With increasing radiation dose, the possibility of tumor control increases but the probability of toxicity to the surrounding normal tissue also increases. The subsequent changes in the normal tissues after radiotherapy can occur within a few minutes, or even several years. The early effects occur in rapidly proliferating tissue and tend to cause inflammation and are usually reversible. The late effects occur in more slowly proliferating tissues and the pathogenesis includes fibrosis, atrophy, and vascular damage. The early and late responses of the normal tissue can be dose-limiting factors in radiotherapy for head and neck cancer, affecting the therapeutic efficacy and quality of life of cancer survivors. Radiation-induced oral mucositis is the major limiting acute toxicity of radiotherapy for head and neck cancers and can lead to treatment interruption and suboptimal disease control. On the other hand, the most problematic late toxicities in the region of the head and neck are decreased secretion of saliva and dysfunction in swallowing. This review investigated the pathophysiology of radiation-induced toxicity: oral mucositis, xerostomia and dysphagia.
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참고문헌 (59)
참고문헌 신청
Borras JM / 2015 / The impact of cancer incidence and stage on optimal utilization of radiotherapy: Methodology of a population based analysis by the ESTRO-HERO project / Radiother Oncol 116:45~50
Browman GP / 1994 / Placebo-controlled randomized trial of infusional fluorouracil during standard radiotherapy in locally advanced head and neck cancer / J Clin Oncol 12:2648~2653
Al-Sarraf M / 1998 / Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099 / J Clin Oncol 16:1310~1317
Adelstein DJ / 1993 / Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: An Eastern Cooperative Oncology Group pilot study / J Clin Oncol 11:2136~2142
Brizel DM / 1998 / Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer / N Engl J Med 338:1798~1804
Browman GP / 1994 / Placebo-controlled randomized trial of infusional fluorouracil during standard radiotherapy in locally advanced head and neck cancer / J Clin Oncol 12:2648~2653
Al-Sarraf M / 1998 / Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099 / J Clin Oncol 16:1310~1317
Adelstein DJ / 1993 / Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: An Eastern Cooperative Oncology Group pilot study / J Clin Oncol 11:2136~2142
Brizel DM / 1998 / Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer / N Engl J Med 338:1798~1804
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