지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 172 - 179 (8page)
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Background and Objectives: The relationship between short-term hypothyroidism due to levothyroxine (LT4) withdrawal for radioactive iodine (RI) therapy in patients with differentiated thyroid cancer (DTC) and risk of cardiovascular disease is not clear. In this study, we evaluated the impact of short-term overt hypothyroidism on lipid profiles and cardiovascular parameters in patients with DTC. Materials and Methods: We recruited 195 patients with DTC who were preparing RI therapy from March 2008 to February 2012. We analyzed the effect of thyroid stimulating hormone (TSH) level on the clinical, biochemical, and cardiovascular risk markers at the end of LT4 withdrawal protocol (P2). Results: After LT4 withdrawal (P2), TSH and total cholesterol (TC) levels were significantly increased (p＜0.005). After adjustment for multiple factors such as age, sex, body mass index (BMI), hypertension and diabetes mellitus (DM), the positive relationship between TSH and TC remained significant (p=0.04). Mean levels of homocysteine, low density lipoprotein-cholesterol, triglyceride were increased. However, levels of high density lipoprotein-cholesterol, cystatin C, C-reactive protein, apolipoprotein B (ApoB), apolipoprotein A1 (Apo A1), lipoprotein (a) (Lp[a]), aspartate transaminase, alanine aminotransferase, total bilirubin, uric acid remained within normal range. Splitting the whole cohort into the three different age groups, serum Apo B, Lp(a) levels and BMI increased with increasing age (p＜0.05). And splitting into three different TSH level groups (1st group; ＜79 μIU/mL, 2nd group; 79-121 μIU/mL, 3rd group; ＞121 μIU/mL), all values did not have a statistical significant meaning except Apo A1. Conclusion: Short-term hypothyroidism induced worsening of lipid metabolic parameters, but not enough to induce the cardiovascular risk in patients with thyroid cancer.
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참고문헌 (20)
참고문헌 신청
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer / 2009 / Revised American Thyroid Association management guidelin
Bicikova M / 2003 / Steroids, sex hormone-binding globulin, homocysteine, selected hormones and markers of lipid and carbohydrate metabolism in patients with severe hypothyro
Botella-Carretero JI / 2004 / Chronic thyrotropinsuppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with un
Botella-Carretero JI / 2006 / Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdra
Catargi B / 1999 / Homocysteine, hypothyroidism, and effect of thyroid hormone replacement / Thyroid 9 (12) : 1163 ~ 1166
Bicikova M / 2003 / Steroids, sex hormone-binding globulin, homocysteine, selected hormones and markers of lipid and carbohydrate metabolism in patients with severe hypothyro
Botella-Carretero JI / 2004 / Chronic thyrotropinsuppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with un
Botella-Carretero JI / 2006 / Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdra
Catargi B / 1999 / Homocysteine, hypothyroidism, and effect of thyroid hormone replacement / Thyroid 9 (12) : 1163 ~ 1166
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