지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Mechanical prophylaxis (MP) and low-molecular-weight heparins (LMWHs) have been widely used after patient undergoing orthopedic surgery. However, their efficacy in preventing venous thrombus remains unclear. Methods : PubMed, Embase and Cochrane library databases were systematically searched for studies that investigated the effectiveness between MP and LMWHs. Predefined outcomes were incidence of deep vein thrombosis (DVT), pulmonary embolism (PE), proximal DVT and major bleeding using random-effects models. Results : A total of 8 randomized controlled trials (RCTs) on 2899 patients were eligible for inclusion. No significant difference was observed between MP and LMWHs for the prevention of DVT (RR 1.37; 95% CI: 0.83-2.26), PE (RR 1.35; 95% CI: 0.41-4.41), or proximal DVT (RR 1.30; 95% CI: 0.55- 3.02). However, there was a significant reduction of major bleeding (RR 0.21; 95% CI: 0.05-0.82). Predefined subgroup analysis suggested that MP might enhance the occurrence of DVT in comparison with fixed-dose LMWHs (RR 1.61; 95% CI: 1.09-2.37), but not in the subgroup with adjusted-weight LMWHs (RR 0.38; 95% CI, 0.11-1.30). Without combining graduated compression stockings (GCS) in both groups, the incidence of DVT was significantly associated with MP (RR 1.88; 95% CI: 1.01-3.21). Conclusions : Results of this meta-analysis suggested, compared to LMWHs, MP might have no significance in the prevention of DVT, although it was associated with lower incidence of major bleeding after patients underwent orthopedic surgery. However, subgroup analyses suggested that fixed-based LMWHs or application one of mechanical types without GCS might have differential effects. Therefore, large-scaled and well-designed RCTs are needed in the future.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Heit JA / 2016 / The epidemiology of venous thromboembolism / J Thromb Thrombolysis 41(1):3~14
Falck-Ytter Y / 2012 / Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines / Chest 141(Suppl 2):e278S~e325S
박신형 / 2016 / Incidences of Deep Vein Thrombosis and Pulmonary Embolism after Total Knee Arthroplasty Using a Mechanical Compression Device with and without Low-Molecular-Weight Heparin / Knee Surgery and Related Research 28(3):213~218
Hill J / 2010 / Reducing the risk of venous thromboembolism in patients admitted to hospital: summary of NICE guidance / BMJ 340(7740):c95
Colwell Jr CW / 2010 / Thrombosis prevention after total hip arthroplasty: a prospective, randomized trial comparing a mobile compression device with low-molecular-weight heparin / JBJS 92(3):527~535
Falck-Ytter Y / 2012 / Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines / Chest 141(Suppl 2):e278S~e325S
박신형 / 2016 / Incidences of Deep Vein Thrombosis and Pulmonary Embolism after Total Knee Arthroplasty Using a Mechanical Compression Device with and without Low-Molecular-Weight Heparin / Knee Surgery and Related Research 28(3):213~218
Hill J / 2010 / Reducing the risk of venous thromboembolism in patients admitted to hospital: summary of NICE guidance / BMJ 340(7740):c95
Colwell Jr CW / 2010 / Thrombosis prevention after total hip arthroplasty: a prospective, randomized trial comparing a mobile compression device with low-molecular-weight heparin / JBJS 92(3):527~535
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Efficacy of Low Molecular Weight Heparin for the Prevention of Venous Thromboembolism after Hip Fracture Surgery in Korean Patients
Yonsei Medical Journal
2016 .01
-
Pharmacological and Mechanical Thromboprophylaxis in Critically Ill Patients: a Network Meta-Analysis of 12 Trials
Journal of Korean Medical Science
2016 .01
-
Hello, DVT
대한외과학회 학술대회 초록집
2022 .11
-
Deep Vein Thrombosis in the Lower Extremities in Comatose Elderly Patients with Acute Neurological Diseases
Yonsei Medical Journal
2016 .01
-
Triaging deep vein thrombosis using ultrasonography after lower-extremity orthopedic surgery: analysis of a single-center experience
ULTRASONOGRAPHY
2021 .01
-
Rivaroxaban versus Low-Molecular- Weight Heparin for Venous Thromboembolism in Gastrointestinal and Pancreatobiliary Cancer
Journal of Korean Medical Science
2019 .01
-
Incidences of Deep Vein Thrombosis and Pulmonary Embolism after Total Knee Arthroplasty Using a Mechanical Compression Device with and without Low-Molecular-Weight Heparin
Knee Surgery and Related Research
2016 .01
-
Comparison of Apixaban and Low Molecular Weight Heparin in Preventing Deep Venous Thrombosis after Total Knee Arthroplasty in Older Adults
Yonsei Medical Journal
2019 .01
-
급성 증상이 있는 폐색전증 환자에서 심부정맥 혈전증의 유병률과 임상적 중요성
대한응급의학회지
2022 .01
-
Detection of Deep Vein Thrombosis by Follow-up Indirect Computed Tomography Venography after Pulmonary Embolism
Tuberculosis and Respiratory Diseases
2018 .01
-
Incidence of Deep Vein Thrombosis after Major Lower Limb Orthopedic Surgery: Analysis of a Nationwide Claim Registry
Yonsei Medical Journal
2015 .01
-
Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty
Knee Surgery and Related Research
2021 .12
-
The Risk of Deep Vein Thrombosis and Optimal Timing of Breast Cancer Surgery After COVID-19 Infection
Journal of Breast Cancer
2024 .08
-
근위부 심부정맥 혈전증에서 유증상 폐색전증과 무증상 폐색전증의 비교
Journal of Yeungnam Medical Science
2017 .01
-
근위부 심부정맥 혈전증에서 유증상 폐색전증과 무증상 폐색전증의 비교
영남의대학술지
2017 .01
-
Significance of preoperative screening of deep vein thrombosis and its indications for patients undergoing urological surgery
Investigative and Clinical Urology
2021 .01
-
Deep Vein Thrombosis Prophylaxis after Total Hip Arthroplasty in Asian Patients
Hip and Pelvis
2018 .01
-
Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis
Cancer Research and Treatment
2019 .01
-
Heart Failure Is Associated with Increased Risk of Long-Term Venous Thromboembolism
Korean Circulation Journal
2021 .09
-
Perioperative Short Term Prophylaxis against Deep Vein Thrombosis after Major Abdominal Cancer Surgery: Retrospective Cohort Study
Vascular Specialist International
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0