지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The osteocyte has long been considered to be the primary mechanosensory cell in thebone. Recent evidence has emerged that the osteocyte is also a key regulator of variousbone and mineral metabolism and that its regulatory effects are in part mediatedthrough locally produced osteocyte-derived factors, such as sclerostin, receptor activa-tor of nuclear factor-kappa B ligand (RANKL), and fibroblast growth factor (FGF)-23. Os-teocytes secrete large amounts of insulin-like growth factor (IGF)-I in bone. AlthoughIGF-I produced locally by other bone cells, such as osteoblasts and chondrocytes, hasbeen shown to play important regulatory roles in bone turnover and developmentalbone growth, the functional role of osteocyte-derived IGF-I in the bone and mineral me-tabolism has not been investigated and remains unclear. However, results of recentstudies in osteocyte Igf1 conditional knockout transgenic mice have suggested potentialregulatory roles of osteocyte-derived IGF-I in various aspects of bone and mineral me-tabolism. In this review, evidence supporting a regulatory role for osteocyte-derivedIGF-I in the osteogenic response to mechanical loading, the developmental bonegrowth, the bone response to dietary calcium depletion and repletion, and in fracturerepair is discussed. A potential coordinated regulatory relationship between the effect ofosteocyte-derived IGF-I on bone size and the internal organ size is also proposed.
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참고문헌 (26)
참고문헌 신청
Atkins GJ. / 2012 / Osteocyte regulation of bone mineral: a little give and take / Osteoporos Int 23 : 2067 ~ 2079
Behringer RR. / 1990 / Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice / Endocrinology. 127 : 1033 ~
Bonewald LF. / 2007 / Osteocytes as dynamic multifunctional cells / Ann N Y Acad Sci. 1116 : 281 ~ 290
Bonewald LF. / 2011 / The amazing osteocyte / J Bone Miner Res. 26 : 229 ~ 238
Feng JQ. / 2013 / Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia
Behringer RR. / 1990 / Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice / Endocrinology. 127 : 1033 ~
Bonewald LF. / 2007 / Osteocytes as dynamic multifunctional cells / Ann N Y Acad Sci. 1116 : 281 ~ 290
Bonewald LF. / 2011 / The amazing osteocyte / J Bone Miner Res. 26 : 229 ~ 238
Feng JQ. / 2013 / Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia
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