지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
The clinical significance of sarcopenia and osteoporosis has increased with the increasein the population of older people. Sarcopenia is defined by decreased muscle mass andimpaired muscle function, which is related to osteoporosis independently and depend-ently. Numerous lines of clinical evidence suggest that lean body mass is positively relat-ed to bone mass, which leads to reduced fracture risk. Genetic, endocrine and mechani-cal factors affect both muscle and bone simultaneously. Vitamin D, the growth hor-mone/insulin-like growth factor I axis and testosterone are physiologically and patho-logically important as endocrine factors. These findings suggest the presence of interac-tions between muscle and bone, which might be very important for understanding thephysiology and pathophysiology of sarcopenia and osteoporosis. Muscle/bone relation-ships include two factors: local control of muscle to bone and systemic humoral interac-tions between muscle and bone. As a putative local inducer of muscle ossification, wefound Tmem119, a parathyroid hormone-responsive osteoblast differentiation factor.
Moreover, osteoglycin might be one of the muscle-derived humoral bone anabolic fac-tors. This issue may be important for the development of novel drugs and biomarkersfor osteoporosis and sarcopenia. Further research will be necessary to clarify the detailsof the linkage of muscle and bone.
목차
등록된 정보가 없습니다.
참고문헌 (79)
참고문헌 신청
Miyakoshi N. / 2013 / Prevalence of sarcopenia in Japanese women with osteopenia and osteoporosis / J Bone Miner Metab. 31:556~561
Bonewald LF. / 2013 / Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop / J Bone Miner Res. 28:1857~1865
Ong T. / 2014 / A United Kingdom perspective on the relationship between body mass index (BMI) and bone health: a cross sectional analysis of data from the Nottingham Fracture Liaison Service / Bone. 59:207~210
Verschueren S. / 2013 / Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men / Osteoporos Int. 24:87~98
Ducher G. / 2011 / Effects of repetitive loading on the growth-induced changes in bone mass and cortical bone geometry: a 12-month study in pre/peri- and postmenarcheal tennis players / J Bone Miner Res. 26:1321~1329
Bonewald LF. / 2013 / Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop / J Bone Miner Res. 28:1857~1865
Ong T. / 2014 / A United Kingdom perspective on the relationship between body mass index (BMI) and bone health: a cross sectional analysis of data from the Nottingham Fracture Liaison Service / Bone. 59:207~210
Verschueren S. / 2013 / Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men / Osteoporos Int. 24:87~98
Ducher G. / 2011 / Effects of repetitive loading on the growth-induced changes in bone mass and cortical bone geometry: a 12-month study in pre/peri- and postmenarcheal tennis players / J Bone Miner Res. 26:1321~1329
이 논문의 저자 정보
최근 본 자료
댓글(0)
0