지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Bisphosphonate generally seems to be safe, but hypocalcemia may occasionally develop in the course of bisphosphonate treatment. Hypocalcemia induced by bisphosphonate is usually mild and asymptomatic, but unrecognized or poorly treated hypocalcemia can lead to life-threatening state. A 78-year-old woman who had a history of hip arthroplasty and intravenous zoledronate treatment for femur neck fracture was presented to emergency department with altered mental status. It turned out that her symptom was due to severe hypocalcemia which was caused by intravenous zoledronate treatment. She also had renal dysfunction. She was treated by intravenous calcium gluconate and calcitriol administration. This case supports the need for evaluation of renal dysfunction, vitamin D deficiency and parathyroid gland dysfunction before bisphosphonate treatment and accurate monitoring of plasma calcium and creatinine levels.
In addition, vitamin D and calcium supply during treatment with bisphosphonate is mandatory.
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참고문헌 (20)
참고문헌 신청
Chesnut CH, 3rd / 1995 / Alendronate treatment of the postmenopausal osteoporotic woman: effect of multiple dosages on bone mass and bone remodeling / Am J Med 99 : 144 ~ 152
Conte PF / 1996 / Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: results from a multinational randomized controlled t
Courtney AE / 2009 / Chronic kidney disease and bisphosphonate treatment: are prescribing guidelines unnecessarily restrictive? / Postgrad Med J 85 : 327 ~ 330
Couttenye MM / 1997 / High prevalence of adynamic bone disease diagnosed by biochemical markers in a wide sample of the European CAPD population / Nephrol Dial Transplant 12
Hamdy RC / 2010 / Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass / Drug Des Devel Ther 4 : 321 ~ 335
Conte PF / 1996 / Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: results from a multinational randomized controlled t
Courtney AE / 2009 / Chronic kidney disease and bisphosphonate treatment: are prescribing guidelines unnecessarily restrictive? / Postgrad Med J 85 : 327 ~ 330
Couttenye MM / 1997 / High prevalence of adynamic bone disease diagnosed by biochemical markers in a wide sample of the European CAPD population / Nephrol Dial Transplant 12
Hamdy RC / 2010 / Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass / Drug Des Devel Ther 4 : 321 ~ 335
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