지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The aim of this in vitro study was to determine the effect of zoledronate,which is frequently used to treat osteoporosis, on osteoarthritis by analyzing zoledro-nate-induced expression of vascular endothelial growth factor-A (VEGF-A) in chondro-cytes and synovial cells. Methods: After chondrocytes and synovial cells were separatedand cultured, zoledronate was added, and VEGF-A and pigment epithelium-derived fac-tor (PEDF) expression were quantified by real-time polymerase chain reaction and West-ern blotting. Results: There was no significant difference in the expression of VEGF-AmRNA in chondrocytes between the zoledronate group and the control group on the8th day of culture. The expression of both VEGF-A and PEDF mRNA in synovial cells wassignificantly decreased in the zoledronate group (P<0.05). Conclusions: Zoledronatedecreases the expression of VEGF-A in synovial cells and may affect the developmentand progression of osteoarthritis.
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참고문헌 (23)
참고문헌 신청
Ashraf S. / 2011 / Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis / Arthritis Rheum. 63 : 2700 ~ 2710
Brandt KD. / 2008 / Etiopathogenesis of osteoarthritis / Rheum Dis Clin North Am. 34 : 531 ~ 559
Broadhead ML. / 2010 / The pathophysiological role of PEDF in bone diseases / Curr Mol Med. 10 : 296 ~ 301
Choi ST. / 2009 / Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model / Clin Rheumato
Di Salvatore M. / 2011 / Anti-tumour and anti-angiogenetic effects of zoledronic acid on human non-small-cell lung cancer cell line / Cell Prolif. 44 : 139 ~ 146
Brandt KD. / 2008 / Etiopathogenesis of osteoarthritis / Rheum Dis Clin North Am. 34 : 531 ~ 559
Broadhead ML. / 2010 / The pathophysiological role of PEDF in bone diseases / Curr Mol Med. 10 : 296 ~ 301
Choi ST. / 2009 / Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model / Clin Rheumato
Di Salvatore M. / 2011 / Anti-tumour and anti-angiogenetic effects of zoledronic acid on human non-small-cell lung cancer cell line / Cell Prolif. 44 : 139 ~ 146
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