인슐린종의 임상적 분석

오승근; 이한별; 이규언; 장진영; 김선회; 윤여규; 이건욱

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자료유형: 학술저널

저자정보: 오승근 이한별 이규언 장진영 김선회 윤여규 이건욱

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제10권 제2호

발행연도: 2010.1

수록면: 99 - 105 (7page)

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연구주제

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연구배경

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연구방법

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Purpose: Insulinoma is a rare disease for which early diagnosis followed by proper surgical management provides a chance for cure. Analyses of clinicopathological features of patients can help optimize the surgical approach in the treatment of insulinoma. Methods: The records of 13 patients (seven male, six female mean age 44.3 years; age range 17∼62 years) who were diagnosed clinically and pathologically with insulinoma and who underwent surgery between March 1997 and April 2007 at the Department of Surgery, Seoul National University Hospital. Hospital in English please were retrospectively examined. Results: All patients had findings compatible with Whipple’s triad. Mean fasting blood sugar was 40.5 mg/dl, serum insulin level was 33.5μU/ml, and insulin-to-glucose ratio was 0.6. A prolonged starvation test was performed on six patients. Tumors were localized in 10 patients with a computed tomography (CT) scan and in three patients with CT angiography. Five tumors were located in the pancreas head and uncinate process, five in the body, and four at the body-tail border and tail. Patients underwent resection of tumorby enucleation, distal pancreatectomy, pylorus-preserving pancreaticoduodenectomy, laparoscopic distal pancreatectomy, and duodenum-preserving resection of pancreas head. Four immediate postoperative complications (fluid collection, pancreatic fistula, delayed gastric emptying) occurred. No symptoms or recurrences were apparent during the median 15 month follow-up. Conclusion: Insulinoma is difficult to diagnose correctly without a prolonged duration of symptoms. Localization of insulinoma can be aided by a CT scan and/or CT angiography. Less aggressive operative procedures such as sim ple enucleation might be a sufficient and feasible procedure for curative resection of benign insulinomas. (Korean J Endocrine Surg 2010;10:99-105)

#인슐린종 #췌장 #도세포종 #췌장신경내분비종양 #Insulinoma #Pancreas #Islet cell tumor #Pancreas neuroendocrine neoplasm

참고문헌 (28)

참고문헌 신청

Abboud B / 2008 / Occult sporadic insulinoma: localization and surgical strategy / World J Gastroenterol 14 : 657 ~ 665

Aoki T / 1999 / Evaluation of preoperative and intraoperative arterial stimulation and venous sampling for diagnosis and surgical resection of insulinoma / Surgery 126 : 968

Ayav A / 2005 / Laparoscopic approach for solitary insulinoma: a multicentre study / Langenbecks Arch Surg 390 : 134 ~ 140

Berends FJ / 2000 / Laparoscopic detection and resection of insulinomas / Surgery 12 : 386 ~ 391

Chang HJ / 1994 / Insulinoma of the pancreas / J Korean Surg Soc 47 : 256 ~ 266

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