방사성 옥소 치료 및 전신스캔 전 처치 시의 갑상선 자극호르몬 농도에 따른 갑상선글로불린의 변화

신동훈; 강윤중; 박주승; 조병선; 김창남; 이민구; 최영진

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자료유형: 학술저널

저자정보: 신동훈 강윤중 박주승 조병선 김창남 이민구 최영진

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제12권 제1호

발행연도: 2012.1

수록면: 21 - 27 (7page)

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연구배경

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Purpose: Periods of L-T4 withdrawal and low iodine diet, which are required prior to the treatment and tracking tests that take place after a thyroidectomy, can be of a long duration and cause suffering for patients. The purpose of this study, conducted in South Korea, was to confirm if periods of L-T4 withdrawal and low iodine diet can be shortened by using TSH level prediction. By inquiring into the correlation between TSH level and serum Tg level, and measurement of the amount of iodine present in urine during the low iodine diet period, a thyroglobulin (Tg) cutoff level can be predicted. Methods: A total of 168 patients were included as research subjects. In each case, L-T4 was suspended 3-4 weeks prior to conducting radioactive iodine ablation and 131I scan, and then a low iodine diet was carried out for 2-4 weeks. Serum TSH, Tg and anti-Tg antibodies were measured on the second week of L-T4 withdrawal, and the spot urine Iodine/Creatinine ratio was measured on the second and fourth week after treatment.Results: Three weeks after L-T4 withdrawal, TSH levels increased to over 30μIU/㎖ in 97.2% of the patients, and serum thyroglobulin levels also increased with TSH level to over 30μIU/㎖. There was no measured difference in the amount of iodine in the subject’s urine during the low iodine diet period. Conclusion: It was found that L-T4 withdrawal can be reduced to 3 weeks or less, and that the Tg cutoff level differs according to TSH level. Based on these results, we suggested that the low iodine diet period can be reduced to 1-2 weeks.

#혈청 갑상선글로불린 #혈청 갑상선자극호르몬 #소변 내 요오드 #분화 갑상선암 #Serum thyroglobulin #Serum TSH #Urine iodine #Differentiated thyroid cancer

참고문헌 (21)

참고문헌 신청

[학술지(정기간행물)] -

Black EG / 1981 / Serum thyroglobulin in thyroid cancer / Lancet 2 : 443 ~ 445

Black EG / 1983 / Should one measure serum thyroglobulin in the presence of anti-thyroglobulin antibodies? / Clin Endocrinol (Oxf) 19 : 597 ~ 601

Black EG / 1987 / Serial serum thyroglobulin measurements in the management of differentiated thyroid carcinoma / Clin Endocrinol (Oxf) 27 : 115 ~ 120

Cooper DS / 2006 / American Thyroid Association Guidelines Taskforce. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 16 :