지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 92 - 97 (6page)
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Purpose: Cyclin D1, cytokeratin(CK)7, CK20 and vimentin play an important role in tumorigenesis and tumor progression. Our aim was to investigate the expression of cyclin D1, CK7, CK20 and vimentin in 138 papillary thyroid cancer and relationship with clinicobiological factors. We also tried to evaluate the value of those as prognostic factors.
Methods: We performed an immunohistochemical assay for cyclin D1, CK7, CK20, and vimentin in 138 papillary thyroid cancer tissue specimens. The correlation between these factors and the clinicobiological parameters was analyzed.
Results: In 138 papillary thyroid carcinoma specimens, the expression of cyclin D1, CK7, CK20 and vimentin was seen in 118 cases (85.5%), 133 cases (96.4%), 2 cases (1.4%) and 119 cases (86.2%), respectively. In our cases, there was a significant association among the expressions of cyclin D1, gender and lymph node metastasis. However, no obvious correlation was found between those proteins, age, tumor size, tumor amount, lymph node status and the TNM stage.
Conclusion: Our results suggested increased cyclin D1 expression was seen in female gender and it may be a useful marker for evaluating lymph node metastasis. However, the clinical utility of cyclin D1, CK7, CK20 and vimentin in thyroid cancer patients has to be further defined by prospective studies with larger sample sizes.
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참고문헌 (23)
참고문헌 신청
Bejarano PA / 2000 / Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms / Appl Immunohistochem Mol Morphol 9 : 189 ~ 194
Bennett GS / 1979 / Redistribution of intermediate filament subunits during skeletal myogenesis and maturation in vitro / J Cell Biol 82 : 577 ~ 584
Blumenberg M / 1992 / Regulation of keratin gene expression: the role of the nuclear receptors for retinoic acid, thyroid hormone, and vitamin D3 / J Invest Dermatol 98 (6) :
Cameron BR / 2003 / Cytokeratin subtypes in thyroid tumours: immunohistochemical study with emphasis on the follicular variant of papillary carcinoma / J Otolaryngol 32 : 31
Campbell F / 2001 / Application of cytokeratin 7 and 20 immunohistochemistry to diagnostic pathology / Current Diagnostic Pathology 7 : 113 ~ 122
Bennett GS / 1979 / Redistribution of intermediate filament subunits during skeletal myogenesis and maturation in vitro / J Cell Biol 82 : 577 ~ 584
Blumenberg M / 1992 / Regulation of keratin gene expression: the role of the nuclear receptors for retinoic acid, thyroid hormone, and vitamin D3 / J Invest Dermatol 98 (6) :
Cameron BR / 2003 / Cytokeratin subtypes in thyroid tumours: immunohistochemical study with emphasis on the follicular variant of papillary carcinoma / J Otolaryngol 32 : 31
Campbell F / 2001 / Application of cytokeratin 7 and 20 immunohistochemistry to diagnostic pathology / Current Diagnostic Pathology 7 : 113 ~ 122
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