소포 변이 유두 갑상선암: 병리학적 소분류에 따른 임상병리학적 특성연구

김예정; 성치원; 박영삼; 김철승; 최은혜; 주명진

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자료유형: 학술저널

저자정보: 김예정 성치원 박영삼 김철승 최은혜 주명진

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제11권 제4호

발행연도: 2011.1

수록면: 256 - 261 (6page)

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이 논문의 연구 히스토리 (2)

2011

소포 변이 유두 갑상선암: 병리학적 소분류에 따른 임상병리학적 특성연구

김예정 , 성치원 , 박영삼 외 3명 The Journal of Endocrine Surgery 2011.01 학술저널

2009

여포변이 유두상 갑상선암 : 임상병리학적 특성 연구

김예정 , 성치원 , 박영삼 외 2명 대한외과학회 학술대회 초록집 2009.11 학술대회자료

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Purpose: The follicular variant of papillary thyroid carcinoma (FVPTC) is difficult to diagnose due to pathologic features. There is also debate on the optimal extent of surgery. We separated FVPTC into two groups and compared the clinical features in an attempt to apply the treatment. Methods: All 40 patients with FVPTC who were diagnosed between 1990 and 2009 were reviewed and separated into two groups, an encapsulated group and an infiltrative group, based on whether a capsule was formed or infiltration occurred. These two different subtypes of FVPTC were compared on the traits of sensitivity of diagnosis and clinicopathologic features. Results: After review by a pathologist, 21 of 40 patients (55%) were found to have encapsulated tumors, and 18 patients (45%) had infiltrative tumors. There was no difference in age, sex, or size. Patients with encapsulated FVPTC had a significantly lower rate of lymph node metastasis (4.5%), multicentric tumors (18.2%), and thyroid capsular invasion (9.1%) compared with the infiltrative tumor group (50%, 50% and 50%, P＜0.05). There was no difference in FNA sensitivity between the two groups, but the sensitivity to frozen biopsy was higher in the infiltrative group. There was no recurrence in the encapsulated group, but 4 patients (22.2%) experienced recurrence in the infiltrative group. Conclusion: FVPTC can be separated into two subgroups by histologic features, and there are some clinicopathologic differences between the two groups. Patients who had encapsulated FVPTC had a lower rate of lymph node metastasis, multicentric tumors, and thyroid capsular invasion. They also showed a lower rate of recurrence than the infiltrative group. It is suggested that the encapsulated group can be treated with limited surgery and the infiltrative group needs aggressive treatment. (Korean J Endocrine Surg 2011;11:256-261)

#갑상선 유두암 #소포변이 #임상병리학적 특성 #피막형군 #침습형 #Thyroid papillary carcinoma #Follicular variant #Clinicopathologic features #Encapsulated type #Infiltrative type

참고문헌 (17)

참고문헌 신청

Baloch ZW / 1999 / Follicular variant of papillary carcinoma. Cytologic and histologic correlation / Am J Clin Pathol 111 : 216 ~ 222

Baloch ZW / 2000 / Encapsulated follicular variant of papillary thyroid carcinoma with bone metastases / Mod Pathol 13 : 861 ~ 865

Burningham AR / 2005 / Papillary and follicular variant of papillary carcinoma of the thyroid: Initial presentation and response to therapy / Otolaryngol Head Neck Surg 132

Chan JK / 1995 / Endocrine malignancies that may mimic benign lesions / Semin Diagn Pathol 12 : 45 ~ 63

Chang HY / 2006 / Clinical presentations and outcomes of surgical treatment of follicular variant of the papillary thyroid carcinomas / Jpn J Clin Oncol 36 : 688 ~ 693