갈색세포종과 복부 부신경절종의 임상적 특성 분석

김상훈; 정승필; 이정희; 김지영; 최민영; 이세경; 최준호; 이정언; 김지수; 남석진; 양정현; 김정한

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자료유형: 학술저널

저자정보: 김상훈 정승필 이정희 김지영 최민영 이세경 최준호 이정언 김지수 남석진 양정현 김정한

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제11권 제4호

발행연도: 2011.1

수록면: 269 - 275 (7page)

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연구주제

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연구배경

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연구방법

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Purpose: We compared clinical characteristics between pheochromocytoma and abdominal paragangliomas and identified predictive factors of malignancy.Methods: Between November, 1995 and January, 2011, we retrospectively reviewed the medical records of 145 patients with pheochromocytoma and abdominal paraganglioma at Samsung Medical Center. We compared two tumors (pheochromocytoma vs abdominal paraganglioma) about a potential of hypersecretion of cathecholamines and identified predictive factors of malignancy by analysis of clinical characteristics, biochemical markers, tumor features. Their postoperative results were also evaluated.Results: This study included 103 (71%) pheochromocytomas and 42 (29%) abdominal paragangliomas. Eighty-six percent were benign and 14% were malignant. Patients with paraganglioma were more predominantly men and exhibited a higher malignancy rate (P＜0.01) than pheochromocytoma patients. Most (95%) pheochromocytoma was hyperfunctional, but abdominal paraganglioma were hyperfunctional in 74%. There were no significant differences in biochemical markers between the pheochromocytoma and paraganglioma groupd. When compared with benign tumor, malignant tumors were significantly related with higher mean PASS (P＜0.01) and higher 24-hour urinary VMA (P=0.02), but not with larger tumor size. Conclusion: It is not easy to distinguish malignant from benign tumors by clinical characteristics and pathologic features in the management of pheochromocytoma and paraganglioma. We should keep in mind that abdominal paraganglioma can be also hyperfunctional in many pheochromocytoma patients and has a higher risk of malignancy. (Korean J Endocrine Surg 2011;11:269-275)

#부신 #악성 갈색세포종 #부신경절종 #Adrenal gland #Malignant pheochromocytoma #Paraganglioma

참고문헌 (25)

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Bertherat J / 2005 / New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas / Horm Metab Res 37 : 384 ~ 390

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