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논문 기본 정보

자료유형
학술저널
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대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제10권 제1호
발행연도
2010.1
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19 - 23 (5page)

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Purpose: X-ray microscopy with synchrotron radiation will soon be a useful tool for innovative x-ray imaging in clinical and laboratory settings. It enables us to observe the detailed internal structure of human tissue samples with great magnification power and excellent resolution. So, it has the possibility to be used for the clinical and research purposes to investigate thyroid diseases if it can effectively evaluate the various conditions of thyroid tissue. To determine the relation with their optical microscopic features, we compared the synchrotron X-ray images of unstained normal and thyroid cancer tissue samples with the histopathologic findings of their adjacent, stained thyroid tissue sections. Methods: An x-ray microscope was installed on a 1B2 beamline with a Pohang Light Source, which is a 3rd generation synchrotron radiation facility with an operating energy of 2.5 GeV at Pohang, Korea. The x-ray energy was set at 11.1 keV and the x-ray beam was monochromatized using a W/B4C monochromator. Formalin-fixed 10μm-thick female thyroid tissues from normal cases and carcinoma cases were attached on Kapton film for the imaging. The sample was positioned 25 m away from the beam source. The x-ray image of the sample was converted into a visual image on the CsI (TI) scintillation crystal, and it was magnified 20 times by the microscopic objective lens. After an additional 10 times digital magnification, this visual image was captured by a full frame CCD camera. Results: The monochromated x-ray microscopic images of the female thyroid tissues of the normal cases and carcinoma cases were obtained with good resolution. These synchrotron images showed the normal follicular structures in the normal thyroid tissue sections and the characteristic severe stromal fibrosis with collagen fiber accumulation in the cancer tissue sections. Conclusion: Owing to the great magnification and excellent resolution, the synchrotron x-ray microscopic images of the normal and cancerous thyroid tissues showed good correspondence with the histopathologic findings of their adjacent, stained tissue sections. So, the x-ray microscopic imaging of thyoid tissue using synchrotron radiation has good potential for use in various clinical and research settings in the future. (Korean J Endocrine Surg 2010;10: 19-23)
#방사광 #X-선 현미경 #갑상선 #Synchrotron #X-ray microscope #Thyroid gland

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참고문헌 (13)

참고문헌 신청
Ando M / 2007 / 2D and 3D refraction based x-ray imaging suitable for clinical and pathological diagnosis / American Institute of Physics 879 : 1899 ~ 1902 google schola Arfelli F / 1998 / Low dose phase contrast x-ray medical imaging / Phys Med Biol 43 : 2845 ~ 2852 google schola Arfelli F / 2000 / Synchrotron light and imaging systems for medical radiology / Nucl Instrum Meth Phys Res A 454 : 11 ~ 25 google schola Choi CH / 2007 / Application of synchrotron radiation imaging for non-destructive monitoring of mouse rheumatoid arthritis model / American Institute of Physics 879 : 1952 ~ google schola Hwu Y / 1999 / Coherence-enhanced synchrotron radiology: Refraction versus diffraction mechanisms / J Appl Phys 86 : 4613 ~ 4618 google schola

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