Clinicopathologic Significance of Gastric Adenocarcinoma with Neuroendocrine Features

Jang Jin Kim; June Young Kim; Hoon Hur; Yong Kwan Cho; Sang-Uk Han

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자료유형: 학술저널

저자정보: Jang Jin Kim June Young Kim Hoon Hur Yong Kwan Cho Sang-Uk Han

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제11권 제4호

발행연도: 2011.1

수록면: 195 - 199 (5page)

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Purpose: Composite neuroendocrine-exocrine carcinomas are malignancies that have two distinct components residing within the same tumor: an adenocarcinomatous portion and a neuroendocrine portion. This is rare in gastric cancers; however, poorly differentiated adenocarcinomas can sometimes reveal evidence of neuroendocrine features (NEF) or be ''mixed endocrine and exocrine carcinomas''. This study aimed to review NEF in gastric adenocarcinoma and to evaluate its prognostic significance. Materials and Methods: We selected 29 patients who were diagnosed with gastric adenocarcinoma with NEF and received gastrectomies at the Department of Surgery, Ajou University Hospital between January 2001 and December 2009. We analyzed the clinicopathologic features of gastric cancer with NEF and the prognosis associated with such tumors. Results: The pathologic result with respect to TNM staging of the gastric cancers with NEF were as follows: 5 cases of T1, 5 cases of T2, 10 cases of T3, and 9 cases of T4. There were 7 cases of N0, 7 cases of N1, 8 cases of N2 and 7 cases of N3. The staging of patients with NEF was higher than that of patients without NEF. Especially tumor lymphovascular invasion rate was 82.8%. The overall survival of patients with gastric cancer characterized by NEF was 73.8 months. Conclusions: Positive NEF status might be correlated with clinicopathologic parameters such as a high stage and high frequency of regional lymph node metastasis.

#Stomach neoplasms #Adenocarcinoma #Neuroendocine tumors

참고문헌 (16)

참고문헌 신청

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