지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 251 - 258 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Although discussion about active treatment of trisomy 18 is increasing,there are no previous articles regarding this subject in Korea. In order to provideobjective data about the clinical characteristics and survival of patients with trisomy18, based on the treatment policy, to medical teams and parents with trisomy 18, wereviewed the medical records of such patients at a single center in Korea.
Methods: This is a retrospective study of 22 patients diagnosed with trisomy 18 at theSamsung Medical Center between 1995 and 2013. We collected data about the clinicalcharacteristics, including demographics, birth history, diagnosis method, and associatedanomalies. We analyzed the survival in days, according to three broad categoriesof treatment policy: give-up, conservative management and active treatment.
Results: Of the 22 patients with confirmed trisomy 18, the majority were female (19,86%). The median gestational age was 39 weeks (range, 31–41 weeks) and the medianbirth weight is 2,029 g (range, 1,130–2,990 g). Among the anomalies associated withtrisomy 18, ventricular septal defect (86%) and patent ductus arteriosus (81%) werethe most common cardiac anomalies; giant cisterna magna (59%) was the mostcommon central nervous system anomaly; and clenched hands (73%) and low setears (59%) were the most common structural anomalies. The survival based on thetreatment policy was the highest in the active treatment group, followed by theconservative management group. The give-up group had the lowest survival.
Conclusion: It is possible to achieve an improvement in both survival and symptomrelief for patients with trisomy 18, despite poor neurological outcome and highmortality. Medical personnel need to provide objective data on trisomy 18 to theparents, and determine the treatment policy through careful discussion.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Baty BJ / 1994 / Natural history of trisomy 18and trisomy 13: I. Growth, physical assessment, medical histories, survival, and recurrence risk / Am J Med Genet 49 : 175 ~ 18
Brewer CM / 2002 / Survival in trisomy 13 and trisomy 18 cases ascertained from population based registers / J Med Genet 39 : e54 ~
Bruns D / 2014 / Twenty-two survivors over the age of 1year with full trisomy 18: presenting and current medical conditions / Am J Med Genet A 164 : 610 ~ 619
Carter PE / 1985 / Survival in trisomy 18. Life tables for use in genetic counselling and clinical paediatrics / Clin Genet 27 : 59 ~ 61
Catlin A / 2010 / Trisomy 18 and choices / Adv Neonatal Care 10 : 32 ~
Brewer CM / 2002 / Survival in trisomy 13 and trisomy 18 cases ascertained from population based registers / J Med Genet 39 : e54 ~
Bruns D / 2014 / Twenty-two survivors over the age of 1year with full trisomy 18: presenting and current medical conditions / Am J Med Genet A 164 : 610 ~ 619
Carter PE / 1985 / Survival in trisomy 18. Life tables for use in genetic counselling and clinical paediatrics / Clin Genet 27 : 59 ~ 61
Catlin A / 2010 / Trisomy 18 and choices / Adv Neonatal Care 10 : 32 ~
이 논문의 저자 정보
최근 본 자료
댓글(0)
0