지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 341 - 351 (11page)
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초록· 키워드
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Neural stem cells (NSCs) are characterized by a capacity for self-renewal, differentiation into multiple neural cell lineages, and migration toward damaged sites in the central nervous system (CNS). NSCs expanded in culture could be implanted into the brain where they integrate into host neural circuitry and stably express foreign genes. It hence appears that transplantation of NSCs has been proposed as a promising therapeutic strategy in neurological disorders. During hypoxic-ischemic (HI)brain injury, factors are transiently elaborated to which NSCs respond by migrating to degenerating regions and differentiating towards replacement of dying neural cells. In addition, NSCs serve as vehicles for gene delivery and appear capable of simultaneous neural cell replacement and gene therapy (e.g. with factors that might enhance neuronal differentiation, neurites outgrowth, proper connectivity,neuroprotection, and/or immunomodulatory substances). When combined with certain synthetic biomaterials, NSCs may be even more effective in ‘engineering’the damaged CNS towards reconstitution. Human NSCs were isolated from the forebrain of an aborted fetus at 13 weeks of gestation and were grown as neurospheres in cultures. After the characterization of human NSCs in preclinical testing and the approval of the IRB, a clinical trial of the transplantation of human NSCs into patients with severe perinatal HI brain injury has been performed. The existing data from these clinical trials have shown to be safe, well tolerated, and of neurologicallysome benefits. Therefore, long-term and large scale multicenter clinical study is required to determine its precise therapeutic effect and safety.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Alvarez-Buylla A / 2004 / For the long run: maintaining germinal niches in the adult brain / Neuron 41 : 683 ~ 686
Ashton RS / 2007 / Scaffolds based on degradable alginate hydrogels and poly (lactideco- glycolide) microspheres for stem cell culture / Biomaterials 28 : 5518 ~ 5525
Cullen DK / 2007 / In vitro neural injury model for optimization of tissue-engineered constructs / J Neurosci Res 85 : 3642 ~ 3651
Dietrich J / 2006 / CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo / J Biol 5 : 22 ~
Fowler CD / 2008 / Estrogen and adult neurogenesis in the amygdala and hypothalamus / Brain Res Rev 57 : 342 ~ 351
Ashton RS / 2007 / Scaffolds based on degradable alginate hydrogels and poly (lactideco- glycolide) microspheres for stem cell culture / Biomaterials 28 : 5518 ~ 5525
Cullen DK / 2007 / In vitro neural injury model for optimization of tissue-engineered constructs / J Neurosci Res 85 : 3642 ~ 3651
Dietrich J / 2006 / CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo / J Biol 5 : 22 ~
Fowler CD / 2008 / Estrogen and adult neurogenesis in the amygdala and hypothalamus / Brain Res Rev 57 : 342 ~ 351
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