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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제12권 제1호
- 발행연도
- 2011.1
- 수록면
- 11 - 21 (11page)
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초록· 키워드
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Effects of carnitine on the atherosclerosis and steatosis of hypercholesterolemic rabbits induced by a high-cholesterol diet (HCD) containing 0.5% cholesterol and 2.0% corn oil were investigated. Male New Zealand white rabbits with hypercholesterolemia (blood cholesterol 1,000-1,500 mg/dl) induced by 2-week feeding HCD, were fed HCD containing 0.008 or 0.075% L-carnitine for additional 8 weeks. Feeding HCD for 10 weeks lead to severe atheromatous change, covering 55.7% of the aortic walls, in addition to profound hepatic steatosis. However, carnitine supplementation recovered the increased low-density lipoproteins and triglycerides and decreased high-density lipoproteins levels following HCD feeding, although the increased cholesterol concentration was not potentially attenuated. Notably, carnitine markedly reduced the atheroma area and hepatic lipid accumulation as well as lipid peroxidation. The results indicate that carnitine exerts anti-atherosclerotic and fatty liver-preventing activities by blocking lipid peroxidation and regulating lipid metabolism.
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참고문헌 (24)
참고문헌 신청
Anitschkow N / 1913 / On experimental cholesterin steatosis and its significance in the origin of some pathological processes [in German] / Zentrbl Allg Pathol Pathol Anat 2
Bae HY / 1999 / The role of oxidized low density lipoprotein in atherogenesis / Diabetes 23 : 7 ~ 11
Bell FP / 1992 / L-Carnitine administration and withdrawal effect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic
Blum A / 2004 / 3-Hydroxy-3-methyiglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), atherosclerosis and coronary syndromes / Atherosclerosis 175 : 1 ~ 4
Diaz M / 2000 / L-Carnitine effects on chemical composition of plasma lipoproteins of rabbits fed with normal and high cholesterol diets / Lipids 35 : 627 ~ 632
Bae HY / 1999 / The role of oxidized low density lipoprotein in atherogenesis / Diabetes 23 : 7 ~ 11
Bell FP / 1992 / L-Carnitine administration and withdrawal effect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic
Blum A / 2004 / 3-Hydroxy-3-methyiglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), atherosclerosis and coronary syndromes / Atherosclerosis 175 : 1 ~ 4
Diaz M / 2000 / L-Carnitine effects on chemical composition of plasma lipoproteins of rabbits fed with normal and high cholesterol diets / Lipids 35 : 627 ~ 632
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