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Background: Electrophysiological study has been known as a useful method to evaluate the therapeutic effect of operationin idiopathic carpal tunnel syndrome (CTS). The purpose of this study was to evaluate the clinical and electrophysiologicalchanges after carpal tunnel release (CTR) compared to the preoperative results. Methods: We analyzed the changesof nerve conduction study (NCS) before and after minimal open carpal tunnel release in 18 patients (25 hands) withCTS. Follow-up study was performed over 6 months after operation. Results: Clinical improvement was seen inall cases after CTR. In contrast, electrophysiological improvement was various depending on the parameters; the meanmedian sensory latency and nerve conduction velocity (NCV) improved significantly (p = 0.001). The mean medianmotor latency also improved, but NCV and compound muscle action potential (CMAP) amplitude did not change. Theextent of improvement was evident in moderate CTS, but not in severe CTS. Conclusions: In this preliminarystudy, all subjects who underwent CTR achieved a clinical relief along with a significant improvement ofelectrophysiological parameters such as median sensory latency, sensory NCV and median distal motor latency. AfterCTR, a number of cases with mild to moderate CTS showed a prominent improvement of clinical and electrophysiologicalparameters, while fewer improvements were seen in severe CTS, although it did not reach the statistical significance. (Korean J Clin Neurophysiol 2014;16:21-26)

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