지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 41 - 47 (7page)
이용수
초록· 키워드
오류제보하기
Discogenic pain can develop into chronic low back pain that is very difficult to treat effectively, because
the pathogenesis of the disease still remains controversial. To clarify the pathogenesis, numerous animal models of intervertebral
disc degeneration have been proposed in the literature, each with attendant advantages and disadvantages. The aim of
this study was to determine the most efficacious method and dose of complete Freund’s adjuvant (CFA) injection into intervertebral
disc to develop a discogenic pain in a rat. Methods: CFA was injected into the L5-L6 or L4-L5 disc of male
Sprague-Dawley rats in various conditions including a dose of CFA (10, 20, or 50 uL), drilling, injection site sealing using
cyanoacrylate, and injection velocity. Sham animals were subjected to the same procedure, except for the CFA injection.
Mechanical and heat allodynia were serially measured at both hindpaws until 8 weeks post-operatively. Serial MRI analyses
were performed to observe degenerative changes of the discs. In addition, CGRP & Substance P-immunoreactivities (ir) in
the superficial dorsal horn were evaluated at 4 weeks using immunohistochemistry. Results: Each condition provoked various
problems such as development of hindpaw paralysis, CFA leakage, and no pain development. Mid-sagittal T2 MRI revealed
no significant degenerative changes in the CFA injected disc. The CGRP-ir of the bilateral superficial dorsal horns at the
level of L5-L6 was significantly increased in the CFA group. Conclusions: A total of 10 uL CFA injection into L5-L6 disc
for a period of 10 minutes using a 26-gauge needle without drilling was the most efficacious way to develop discogenic
pain animal model.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Antti-Poika I / 1990 / Clinical relevance of discography combined with CT scanning. A study of 100 patients / J Bone Joint Surg Br 72 : 480 ~ 485
Aoki Y / 2004 / Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats / Spine 29 : 2621 ~
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / Journal of Neuroscience Methods 53 : 55 ~ 63
Freemont AJ / 1997 / Nerve ingrowth into diseased intervertebral disc in chronic back pain / Lancet 350 : 178 ~ 181
Hanft JR / 1991 / Peripheral neuropathy as a result of cyanoacrylate toxicity / J Am Podiatr Med Assoc 81 : 653 ~ 655
Aoki Y / 2004 / Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats / Spine 29 : 2621 ~
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / Journal of Neuroscience Methods 53 : 55 ~ 63
Freemont AJ / 1997 / Nerve ingrowth into diseased intervertebral disc in chronic back pain / Lancet 350 : 178 ~ 181
Hanft JR / 1991 / Peripheral neuropathy as a result of cyanoacrylate toxicity / J Am Podiatr Med Assoc 81 : 653 ~ 655
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