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자료유형
학술저널
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대한족부족관절학회 대한족부족관절학회지 대한족부족관절학회지 제22권 제1호
발행연도
2018.1
수록면
38 - 43 (6page)

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Purpose: Treatment of diabetic foot infection due to methicillin-resistant Staphylococcus aureus (MRSA) remains challenging. Applying vancomycin-impregnated cement is one of the best methods of treatment. Vancomycin-impregnated cement has been used worldwide; however, to date, there is a limited number of studies regarding its use. We evaluated the duration of antimicrobial activity of vancomy- cin-impregnated cement stored at room temperature after manufacturing. Materials and Methods: The vancomycin-impregnated cement was manufactured by mixing 1 g of vancomycin with 40 g of polymer and adding 17.90 g of liquid monomer. The cement dough was shaped into flat cylinders with diameter and height of 6 mm and 2 mm, respectively. Another cement of the same shape without mixing vancomycin was prepared as the negative control. All manufactured cements were sterilized with ethylene oxide gas and stored at room temperature. Each cement was placed on Mueller Hinton agar plate lawned with standard MRSA strain. Standard vancomycin disk and gentamicin disk were placed together. After 24 hours, the diameter of inhibition zone was measured, and if the diameter was less than 15 mm, vancomycin-impregnated cement was regarded as a loss of antimicrobial activity. The study was repeated every 2 weeks until vancomycin-impregnated cements lost their antimicrobial activity. Results: Vancomycin-impregnated cement stored for a duration of 16 weeks created a 14 mm inhibition zone, while vancomycin disk created a 15 mm inhibition zone. Vancomycin-impregnated cement stored for a duration of 17 weeks created 7 mm and 9 mm inhibition zones, while vancomycin disk created 16 mm and 15 mm inhibition zones, respectively. Conclusion: We found a decrease of antimicrobial activity in vancomycin-impregnated cements after 16 weeks. After 17 weeks, they showed definite loss of antimicrobial activity. Therefore, we recommend not using vancomycin-impregnated cement spacers that has been stored for more than 16 weeks at room temperature.

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참고문헌 (18)

참고문헌 신청
Yu Jin Kim / 2019 / Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea / The Korean Journal of Internal Medicine 34(1):125~136 Crossref Shaw JE / 2010 / Global estimates of the prevalence of diabetes for 2010 and 2030 / Diabetes Res Clin Pract 87:4~14 Crossref Hartemann-Heurtier A / 2008 / Diabetic foot osteomyelitis / Diabetes Metab 34:87~95 Crossref Berendt AR / 2008 / Diabetic foot osteomyelitis: a progress report on diagnosis and a systematic review of treatment / Diabetes Metab Res Rev 24(Suppl 1):S145~S161 Crossref Lipsky BA / 2012 / 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections / Clin Infect Dis 54:e132~e173 Crossref

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