Immunoglobulin G4-Related Disease Masquerading Anaplastic Thyroid Carcinoma

김지아; 조민규; 김석현; 김영금; 차원재

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자료유형: 학술저널

저자정보: 김지아 조민규 김석현 김영금 차원재

저널정보: 대한이비인후과학회 부산,울산,경남 지부회 임상이비인후과 임상이비인후과 제29권 제2호

발행연도: 2018.1

수록면: 301 - 306 (6page)

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Immunoglobulin G4-related disease (IgG4RD) is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, as well as varying degrees of fibrosis. We report a case of a 70-year-old man with a rapid-growing cervical mass for several months. Computed tomography and positron emission tomography showed a huge, ill-defined mass involving left thyroid lobe and encasing the common carotid artery, which was clinically and radiologically suspicious for anaplastic thyroid carcinoma. Ultrasonography-guided core needle biopsy was performed and histopathology examination revealed to be consistent with IgG4RD, and the IgG4/IgG ratio was 0.6. After oral corticosteroid was administered, the mass was dramatically resolved. Because IgG4RD often presents as a single localized and infiltrated mass lesion, it can be confused and misdiagnosed as a malignancy. Thus, clinicians should consider IgG4RD as a differential diagnosis in a rapid-growing neck mass to prevent unnecessary and excessive treatments.

참고문헌 (17)

참고문헌 신청

Stone JH / 2012 / Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations / Arthritis Rheum 64(10):3061~3067

Park HG / 2016 / IgG4-related inflammatory pseudotumor of the renal pelvis involving renal parenchyma, mimicking malignancy / Diagn Pathol 11(1):12

Mulholland GB / 2015 / Immunoglobulin G4-related diseases in the head and neck : a systematic review / J Otolaryngol Head Neck Surg 44:24

McKinnon T / 2015 / IgG4-Related Disease Presenting as a Solitary Neck Mass / J Radiol Case Rep 9(2):1~8

Umehara H / 2012 / A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details / Mod Rheumatol 22(1):1~14

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