지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 67 - 72 (6page)
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초록· 키워드
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Objectives: This study evaluated the single-dose toxicity of Saeng Maek San (SMS) in rats.
Methods: All experiments were conducted at Biotoxtech (Chungwon, Korea), an institute authorized to perform non-clinical studies under the regulations of Good Laboratory Practice (GLP). A single-dose intravenous toxicity study was carried out on 40 6-week-old Sprague-Daley rats. The animals were randomly divided into the following four groups of ten animals each: Group 1 (G1) was the control group, with each animal receiving an intravenous injection of 1.0 mL of saline, and Groups 2, 3 and 4 (G2, G3 and G4) were the experimental groups, with the animals in the groups receiving an injection of 0.1, 0.5 and 1.0 mL of SMS, respectively. Mortality, clinical signs, body-weight changes and gross pathological findings were observed for 14 days following a single administration of SMS or saline. Organ weights, clinical chemistry and hematology were analyzed at 14 days. This study was conducted with the approval of the Institutional Animal Ethics Committee.
Results: No deaths occurred in any of the four groups, indicating that the lethal dose of SMS in rats is greater than 1.0 mL/animal. Some changes in weights of male rats between the control group and the experimental groups were observed, but no significant changes in the weights of female rats were noted. To identify abnormalities in organs and tissues, we stained representative sections of each specified organ with hematoxylin and eosin for examination with a light microscope. No significant abnormalities were observed in any of the organs or tissues.
Conclusion: The results suggest that intravenous injection of Saeng Maek San is a safe method of treatment.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Chen Z. / 2010 / Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity : with emphasis on autophagy / Neurosci Lett 482 (3) : 264 ~ 268
Cheng HY. / 2008 / Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity / J Pharmacol Sci 107 (1) : 21 ~ 31
Chiu PY. / 2011 / Co-treatment with Shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats / Rejuvenation Res 14 (1) : 17 ~ 23
Guo Z. / 2014 / A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/ mT
Gurney ME. / 1994 / Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation / Science 264 (5166) : 1772 ~ 1775
Cheng HY. / 2008 / Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity / J Pharmacol Sci 107 (1) : 21 ~ 31
Chiu PY. / 2011 / Co-treatment with Shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats / Rejuvenation Res 14 (1) : 17 ~ 23
Guo Z. / 2014 / A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/ mT
Gurney ME. / 1994 / Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation / Science 264 (5166) : 1772 ~ 1775
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