지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 29 - 33 (5page)
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초록· 키워드
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Objectives: Much evidence exists that herbs have effective immunomodulatory activities. Chrysanthemi Flos (CF) is effective in clearing heat, reducing inflammation, dropping blood pressure and treating headache and is used as a pharmaceutical raw material for an immune enhancer. The purpose of this study was to investigate the modulatory effect of Chrysanthemi Flos pharmacopuncture on nitric-oxide (NO) production in activating macrophages.
Methods: After a murine macrophage cell line, RAW 264.7,was cultured in the presence of lipopolysaccharide (LPS),immune-modulating abilities of CF were evaluated by using NO, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) production and phagocytic activity of macrophages.
Results: CF enhanced the activities of macrophages by increasing the phagocytic activity and decreasing NO production.
Especially, both LPS and CF, 200 ㎍/ml, treatment could significantly reduce the NO production, but did not change the production of IL-6 and TNF-α.
Conclusion: The results of this study indicate that CF may be of immunomodulatory value, especially for adverse diseases due to increased NO production. It may have potential for use as immunoenhancing pharmacopuncture.
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참고문헌 (24)
참고문헌 신청
Akira S. / 2001 / Toll-like receptors : critical proteins linking innate and acquired immunity / Nature Immu
Amirghofran Z. / 2011 / The effect of the methanol extract of Galium mite on the cellular immunity and antibody synthesis / J Immunoassay Immunochem 32 (3) : 157 ~ 169
Amrouche T. / 2006 / Production and characterization of anti-bifidobacteria monoclonal antibodies and their application in the development of an immuno-culture detection meth
Cai Y. / 2011 / Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM / Cell Mol Immunol
Chen JL. / 2004 / Chinese Medical Herbology and Pharmacology / Art of Medicine Press : 58 ~ 61
Amirghofran Z. / 2011 / The effect of the methanol extract of Galium mite on the cellular immunity and antibody synthesis / J Immunoassay Immunochem 32 (3) : 157 ~ 169
Amrouche T. / 2006 / Production and characterization of anti-bifidobacteria monoclonal antibodies and their application in the development of an immuno-culture detection meth
Cai Y. / 2011 / Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM / Cell Mol Immunol
Chen JL. / 2004 / Chinese Medical Herbology and Pharmacology / Art of Medicine Press : 58 ~ 61
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