지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 7 - 10 (4page)
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초록· 키워드
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Objectives: The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns,frostbite and skin diseases such as eczema and psoriasis.
Methods: In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model.
Results: Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB.
Topical application of LR also inhibited hyperplasia, edema,spongiosis and infiltrations of mononuclear cells. In addition,production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo.
Conclusions: These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.
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참고문헌 (16)
참고문헌 신청
Bickers DR. / 2006 / Oxidative stress in the pathogenesis of skin disease / J Invest Dermatol 126 (12) : 2565 ~ 2575
Boerrigter GH. / 1988 / Hapten-specific antibodies in allergic contact dermatitis in the guinea pig / Int Arch Allergy Appl Immunol 85 (4) : 385 ~ 391
Broide DH. / 2001 / Molecular and cellular mechanisms of allergic disease / J Allergy Clin Immunol. 108 (2 Suppl) : S65 ~ 71
Chen X. / 2003 / Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1 / Antimicrob Agents
Cohen D. / 2004 / Treatment of irritant and allergic contact dermatitis / Dermatol Ther 17 (4) : 334 ~ 340
Boerrigter GH. / 1988 / Hapten-specific antibodies in allergic contact dermatitis in the guinea pig / Int Arch Allergy Appl Immunol 85 (4) : 385 ~ 391
Broide DH. / 2001 / Molecular and cellular mechanisms of allergic disease / J Allergy Clin Immunol. 108 (2 Suppl) : S65 ~ 71
Chen X. / 2003 / Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1 / Antimicrob Agents
Cohen D. / 2004 / Treatment of irritant and allergic contact dermatitis / Dermatol Ther 17 (4) : 334 ~ 340
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